Key takeaways
Zyrtec-D (cetirizine/pseudoephedrine) and Flonase (fluticasone) are both used to treat allergy symptoms, but they work in different ways and have different forms. Zyrtec-D is a combination of an antihistamine (cetirizine) and a decongestant (pseudoephedrine) taken orally, which helps with inflammation and clears sinuses. It can cause trouble sleeping if taken too close to bedtime and may raise blood pressure, especially in people with hypertension. Flonase, on the other hand, is a nasal spray corticosteroid that reduces inflammation in your nose to relieve symptoms like sneezing, runny nose, and itchy eyes. It must be used daily for the best results and can be used for up to 6 months in adults (or 2 months in children) without a prescription. Flonase can cause nosebleeds and, in children, may slow growth if used for longer periods. Both are available over the counter and as generic versions. Zyrtec-D requires a photo ID to purchase due to pseudoephedrine regulations.
