Key takeaways
Tizanidine (Zanaflex) and diazepam (Valium) are both medications that can be used to treat muscle-related issues, but they belong to different medication classes. Tizanidine is an alpha-2 adrenergic receptor agonist primarily used as a muscle relaxer for muscle stiffness and rigidity, while diazepam is a benzodiazepine used for anxiety, alcohol withdrawal, muscle spasms, and seizures. Tizanidine is taken orally, usually three times a day, and is available in both tablet and capsule forms, with a lower-cost generic option. Diazepam can be taken orally or by injection up to 4 times daily and is available as tablets and liquid solutions. Tizanidine is not a controlled substance, but diazepam is a Schedule IV controlled substance due to its potential for misuse and dependence. Common side effects of tizanidine include dry mouth, sleepiness, and dizziness, while diazepam can cause sleepiness, dizziness, and muscle weakness. Some medications, like ciprofloxacin, can worsen low blood pressure and dizziness when taken with tizanidine. Other medications, like benzodiazepines and opioids, can increase the risk for dangerously slow breathing when taken with diazepam.
