Key takeaways
Tizanidine (Zanaflex) and cyclobenzaprine (Flexeril) are both muscle relaxants used to treat muscle-related conditions. Tizanidine is an alpha-2 adrenergic receptor agonist, while cyclobenzaprine is a general muscle relaxant. Tizanidine is typically used for muscle stiffness and rigidity, often related to conditions like multiple sclerosis, and is taken up to three times a day. Cyclobenzaprine is used for short-term relief of muscle discomfort from acute conditions and is available in both immediate-release and extended-release forms. Tizanidine is available as a lower-cost generic and can be taken with or without food, but food affects its absorption. Cyclobenzaprine is also available as a generic and can be taken with or without food, but food might help with absorption. Common side effects of tizanidine include dry mouth, sleepiness, and dizziness, while cyclobenzaprine can cause drowsiness, dry mouth, and dizziness. Tizanidine can interact with medications like ciprofloxacin, leading to low blood pressure, while cyclobenzaprine can interact with antidepressants, potentially causing serotonin syndrome.
