Key takeaways
Pseudoephedrine (Sudafed) and brompheniramine/phenylephrine (Dimetapp Cold and Allergy) are both over-the-counter medications used to relieve symptoms of nasal congestion from conditions like allergies and the common cold. However, they have some important differences. Pseudoephedrine is a decongestant that works by narrowing blood vessels in the nasal passages, while brompheniramine/phenylephrine combines an antihistamine and a decongestant to address a broader range of symptoms, including runny nose and itchy eyes. Pseudoephedrine is available in various formulations, including immediate and extended-release tablets, and is restricted for purchase at the pharmacy counter due to the potential for misuse. In contrast, brompheniramine/phenylephrine is available in liquid and tablet forms and can be found on store shelves. Common side effects of pseudoephedrine include anxiety and headache, while brompheniramine/phenylephrine may cause dizziness and sleepiness. Both medications can raise blood pressure, so it's important to consult with a healthcare provider if you have heart problems or high blood pressure. Do not take either medication within 2 weeks of monoamine oxidase inhibitors (MAOIs) like selegiline (Eldepryl) or phenelzine (Nardil).
