Key takeaways
Metaxalone (Skelaxin) and cyclobenzaprine (Flexeril) are both muscle relaxants used to treat muscle pain and discomfort, but they have some differences. Metaxalone is typically taken three to four times a day, while cyclobenzaprine is available in both immediate-release (IR) tablets taken three times a day and extended-release (ER) capsules taken once a day. Cyclobenzaprine can cause more drowsiness, especially in its IR form, compared to metaxalone, which is less likely to make you sleepy. Metaxalone is not recommended for people with severe kidney or liver problems, whereas cyclobenzaprine should be used cautiously in those with liver issues and is not recommended for people with certain heart conditions. Both medications can interact with antidepressants and other drugs that affect serotonin levels, potentially leading to a serious condition called serotonin syndrome. Additionally, cyclobenzaprine can cause dry mouth and other anticholinergic side effects, which are less common with metaxalone. Both medications are available as lower-cost generics.
