Key takeaways
Rocklatan (netarsudil/latanoprost) and Vyzulta (latanoprostene bunod) are both eye drop medications used to lower high pressure in the eye, such as in glaucoma. Rocklatan is a combination of two medications: netarsudil, a ROCK inhibitor, and latanoprost, a prostaglandin. Vyzulta, on the other hand, contains latanoprostene bunod, which is another prostaglandin. Unlike other prostaglandins, Vyzulta is the only one that also releases nitric oxide along with latanoprost acid, working in two ways to help lower eye pressure. While both medications are used once daily in the evening, Rocklatan needs to be refrigerated initially but can be stored for up to 6 weeks after opening, whereas Vyzulta can be stored at room temperature for up to 8 weeks after opening. Rocklatan is currently only available as a brand-name product, with no generic version expected before 2034, while Vyzulta also does not have a generic form. Both medications can cause side effects like eye redness and pain, and they can also darken the color of your eyes, eyelashes, and eyelids. However, Rocklatan may cause additional side effects such as corneal deposits and a red spot in the eye.
