Key takeaways
Methocarbamol (Robaxin) and cyclobenzaprine (Flexeril) are both muscle relaxants used to treat muscle pain and discomfort. Methocarbamol is typically taken 3 to 4 times a day, while cyclobenzaprine is available in both immediate-release (IR) tablets taken 3 times a day and extended-release (ER) capsules taken once a day. Cyclobenzaprine is more likely to cause drowsiness and dry mouth compared to methocarbamol. Methocarbamol starts working within 30 minutes and lasts about 6 hours, whereas cyclobenzaprine IR tablets take about an hour to kick in and last 4 to 6 hours. Cyclobenzaprine can interact with certain antidepressants and cause a serious condition called serotonin syndrome, which is not a known risk with methocarbamol. Both medications should be used with caution if you are over 65 years old or taking other medications that cause drowsiness.
