Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Rhinocort Allergy (budesonide) and Nyquil Cold and Flu (acetaminophen/dextromethorphan/doxylamine) are both used to treat symptoms related to respiratory issues, but they work differently and are used for different conditions. Rhinocort Allergy is a corticosteroid nasal spray that helps reduce inflammation in your nose to treat allergy symptoms like sneezing, runny nose, and itching. It is available over-the-counter and as a lower-cost generic. You use it once daily, and it can take up to two weeks to feel the full benefit. On the other hand, Nyquil Cold and Flu is a combination of a pain reliever, cough suppressant, and antihistamine, used to relieve cold and flu symptoms such as cough, sore throat, fever, and runny nose. It works quickly, within 30 minutes, but may need to be taken multiple times a day. Nyquil can make you very sleepy and should not be used long-term. Unlike Rhinocort, Nyquil is available in both liquid and capsule forms. While Rhinocort is focused on treating allergies, Nyquil addresses a broader range of cold and flu symptoms.
Budesonide (Rhinocort Allergy)
Nyquil cold and flu
Budesonide (Rhinocort Allergy)
Nyquil cold and flu
Summary of Rhinocort Allergy vs. Nyquil
Summary for Corticosteroid
Budesonide (Rhinocort Allergy) is an over-the-counter (OTC) nasal spray for adults and children age 6 years and older. It's a corticosteroid that relieves nasal allergy symptoms, such as runny or stuffy nose, itchy nose, and sneezing. Budesonide (Rhinocort Allergy) is sprayed into each nostril once per day. Side effects can include nose bleeds and irritation in the nose. This medication is available as a generic.
Summary for Analgesic / Cough suppressant / Antihistamine
Nyquil Cold and Flu is a combination medication containing acetaminophen (a pain reliever), dextromethorphan (a cough suppressant), and doxylamine (an antihistamine). It's used to treat cold and flu symptoms, like sore throat, fever, cough, runny nose, sneezing, and aches, in adults and children. Nyquil Cold and Flu is available as pills and a liquid. This medication can make you feel sleepy and dizzy as side effects.