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Restoril vs. Trazodone

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Temazepam (Restoril) and trazodone are both used to help with sleep, but they are quite different. Temazepam is a benzodiazepine, which means it works by slowing down brain activity to help you fall asleep and stay asleep. It's only recommended for short-term use (7 to 10 days) because it can be addictive and cause withdrawal symptoms if stopped suddenly. Trazodone, on the other hand, is an atypical antidepressant that is sometimes used off-label for sleep. It affects serotonin levels in the brain and is not addictive, so it doesn't have the same risk of misuse as temazepam. Temazepam is a controlled substance, while trazodone is not. Temazepam is typically taken once a day at bedtime, whereas trazodone can be taken once or a few times a day, depending on your condition. Both medications can cause drowsiness and dizziness, but trazodone also has a higher risk of causing dry mouth and headaches.

Temazepam

(Restoril)

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Trazodone

 

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Summary for Restoril

Prescription only

Temazepam (Restoril) is a short-term option for people who have insomnia (trouble sleeping). It's a benzodiazepine, so taking it can lead to misuse, addiction, and sometimes cause withdrawal symptoms if you suddenly stop taking it. For this reason, it's a controlled substance, so you'll need close follow-up with your provider to make sure this medication remains safe for you to take. Common side effects include drowsiness, headache, nervousness, and sometimes a "hangover" feeling the next morning after your dose. The medication available as a brand name (Restoril) and a generic version.

Indications for Restoril

  • Short-term treatment of insomnia (trouble sleeping)

Pros and Cons for Restoril

Pros

  • Can help you fall asleep and stay asleep throughout the night
  • Only taken once a day at bedtime
  • Dose can be adjusted by your provider based on your response
  • Available as a lower-cost generic

Cons

  • Can cause memory problems, dizziness, and confusion
  • Can worsen suicidal thoughts in some people with depression
  • Can cause withdrawal symptoms if stopped suddenly
  • Only recommended for short-term use (7 to 10 days)
  • Not recommended in pregnancy or breastfeeding

Common Side Effects for Restoril

  • Drowsiness (9%)
  • Headache (9%)
  • Fatigue or exhaustion (5%)
  • Nervousness (5%)
  • Tiredness (5%)
  • Dizziness (5%)
  • Nausea (3%)

Warnings for Restoril

  • Sedation and difficulty breathing
  • Risk of misuse and addiction
  • Risk of dependence and withdrawal
  • Complex behaviors
  • Harm to babies
  • Suicidal thoughts and behaviors
  • Severe allergic reactions

Summary for Trazodone

Prescription only

Trazodone is an atypical antidepressant. It's FDA-approved to treat depression in adults, but it isn't a first-choice option. In addition, trazodone is sometimes prescribed off-label for difficulty sleeping (insomnia). This medication is taken by mouth, typically once or a few times a day, depending on your condition. Common side effects of this medication include sleepiness, dry mouth, and dizziness. Brand name Desyrel has been discontinued.

Indications for Trazodone

Pros and Cons for Trazodone

Pros

  • Taken by mouth
  • Fewer sexual side effects than some other antidepressants
  • Available as a lower-cost generic
  • Starts to work within a week for treating depression

Cons

Common Side Effects for Trazodone

  • Sleepiness (up to 41%)
  • Dry mouth (up to 34%)
  • Dizziness or lightheadedness (up to 28%)
  • Headache (up to 20%)
  • Blurred vision (up to 15%)
  • Nausea or vomiting (up to 13%)

Warnings for Trazodone

  • Worsening depression, suicidal thoughts, and unusual behavior
  • Serotonin syndrome
  • Life-threatening abnormal heart rhythm (QT prolongation)
  • Difficulty concentrating and extreme sleepiness
  • Dizziness from lower blood pressure
  • Risk of bleeding
  • Prolonged and painful erection
  • Glaucoma
  • Low blood sodium levels
  • Withdrawal

Prices with our coupons for Restoril vs. Trazodone

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Temazepam30 capsules / 30mg
$12.78$20.99
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Trazodone30 tablets / 50mg
$9.00$9.00
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