Key takeaways
Norco (hydrocodone / acetaminophen) and tramadol (Conzip, Qdolo) are opioid medications. They’re prescribed to treat moderate-to-severe pain that isn't relieved by non-opioid pain medications. They’re both controlled substances and have side effects such as sleepiness, dizziness, and constipation. Both medications can lead to potential misuse and overdose, especially when combined with other substances that cause drowsiness,such as benzodiazepines and alcohol. One difference between the two medications is that tramadol is longer-acting than Norco. Though it’s rare, tramadol can increase your seizure risk and cause serotonin syndrome. These are also possible with Norco as well, but it’s even less likely.
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