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Nextstellis vs. Yasmin

Nextstellis is a combination birth control pill that's used to help prevent pregnancy. It contains two hormones: drospirenone and estetrol. Nextstellis is the first birth control pill that contains estetrol, a new type of estrogen approved in over 60 years that's also made from a plant source. Each blister card has 24 pink active pills and 4 white inactive pills. Each pill is taken by mouth once daily in the order noted in the instructions. The active pills are monophasic, meaning they contain the same amount of hormones throughout the entire pack. Side effects include irregular vaginal bleeding and mood changes.

• To prevent pregnancy

• Mood changes or mood swings (11%)
• Irregular vaginal bleeding (10%)
• Breast symptoms, like changes in color or size, breast pain, or swelling (5%)
• Headache (5%)

• Cigarette smoking and risk for blood clots
• Blood clots and other complications
• High potassium levels in the blood
• High blood pressure
• Stop taking if you have a migraine
• Risk for breast and cervical cancer
• Liver or gallbladder problems
• High blood sugar
• High cholesterol levels
• Possible need for changes to thyroid hormone replacement therapy
• Irregular bleeding
• Depression
• Worsening of other health conditions

Yasmin is a combination oral contraceptive (COC) that's taken by mouth every day to prevent pregnancy. It's a monophasic COC, which means that all active tablets contain the same dose of hormones. Yasmin contains slightly more estrogen than other birth control options that are similar, so it might cause more side effects.

• Prevention of pregnancy

• Premenstrual syndrome (PMS) (13%)
• Headache/migraine (11%)
• Breast pain/tenderness/discomfort (8%)
• Nausea/vomiting (5%)

• Cigarette smoking and serious heart problems
• Blood clots and stroke
• Risk of breast and cervical cancer
• Liver problems
• High blood pressure
• High blood sugar and lipids (fats)
• Headache
• Depression
• Interactions with other medications
• High potassium