Key takeaways
Drospirenone / ethinyl estradiol (Yaz) and norethindrone acetate / ethinyl estradiol / ferrous fumarate (Lo Loestrin Fe) are both oral contraceptives used to prevent pregnancy. They belong to the estrogen / progestin combined contraceptive medication class. While both medications are effective in preventing pregnancy, Yaz is also FDA-approved to treat premenstrual dysphoric disorder (PMDD) and acne, whereas Lo Loestrin Fe is not. Yaz is a monophasic pill with 24 active hormone tablets and 4 placebo tablets, while Lo Loestrin Fe is biphasic, containing 26 active tablets and 2 placebo tablets with iron. Yaz has branded generic versions available, including Nikki, Jasmiel, and Lo-Zumandimine, while Lo Loestrin Fe does not have a lower-cost generic option. Common side effects of Yaz include nausea, headache, and weight gain, while Lo Loestrin Fe may cause nausea, headache, and irregular bleeding. Both medications can increase the risk of blood clots, especially if you smoke and are over 35 years old. It's important to take these medications as directed and discuss any concerns with your healthcare professional.
