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Nextstellis vs. Yaz

Nextstellis is a combination birth control pill that's used to help prevent pregnancy. It contains two hormones: drospirenone and estetrol. Nextstellis is the first birth control pill that contains estetrol, a new type of estrogen approved in over 60 years that's also made from a plant source. Each blister card has 24 pink active pills and 4 white inactive pills. Each pill is taken by mouth once daily in the order noted in the instructions. The active pills are monophasic, meaning they contain the same amount of hormones throughout the entire pack. Side effects include irregular vaginal bleeding and mood changes.

• To prevent pregnancy

• Mood changes or mood swings (11%)
• Irregular vaginal bleeding (10%)
• Breast symptoms, like changes in color or size, breast pain, or swelling (5%)
• Headache (5%)

• Cigarette smoking and risk for blood clots
• Blood clots and other complications
• High potassium levels in the blood
• High blood pressure
• Stop taking if you have a migraine
• Risk for breast and cervical cancer
• Liver or gallbladder problems
• High blood sugar
• High cholesterol levels
• Possible need for changes to thyroid hormone replacement therapy
• Irregular bleeding
• Depression
• Worsening of other health conditions

Yaz is a combination birth control pill taken daily to prevent pregnancy. It contains 2 medications: drospirenone (a progestin) and ethinyl estradiol (an estrogen). In addition to birth control, it's FDA approved to treat premenstrual dysphoric disorder (PMDD) and acne. Each 28-day pack contains 24 active hormone tablets and 4 placebo tablets. Possible side effects include nausea, headache, and weight gain.

Branded generics that are like the brand-name product Yaz include Nikki, Jasmiel, and Lo-Zumandimine.

• To prevent pregnancy
• Premenstrual dysphoric disorder (PMDD)
• Acne (in people 14 years and older who've started their periods)

Pregnancy prevention and acne:

• Headache or migraine (7%)
• Irregular menstrual bleeding (5%)
• Nausea or vomiting (4%)
• Breast pain or tenderness (4%)

PMDD:

• Irregular menstrual bleeding (25%)
• Nausea (16%)
• Headache (13%)
• Breast tenderness (11%)
• Tiredness (4%)

• Cigarette smoking and serious heart problems
• Risk of blood clot
• High potassium
• Breast and cervical cancer
• Liver problems
• Gallbladder problems
• High blood pressure
• High blood sugar and triglycerides
• Headache
• Irregular bleeding
• Depression
• Worsening of other health conditions