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Lunesta vs. Butisol

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Lunesta (eszopiclone) and Butisol (butabarbital) are both medications used to help with sleep, but they have some key differences. Lunesta is a sedative-hypnotic that is available as a generic and is used to treat insomnia by helping you fall asleep faster and stay asleep longer. It is a Schedule IV controlled substance, meaning it has some potential for misuse and dependence. On the other hand, Butisol is a barbiturate that was known for its fast-acting effects but has been discontinued and is no longer available in the U.S. as either a brand or generic medication. Butisol was a Schedule III controlled substance, indicating a higher potential for misuse compared to Lunesta. While Lunesta can cause side effects like a bad taste in the mouth and headache, Butisol was known to be habit-forming and addicting. If you need a sleep aid, Lunesta is still an option, but Butisol is not available anymore.

Lunesta

(eszopiclone)

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Butisol

(butabarbital)

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Summary for Lunesta

Prescription only

Lunesta (eszopiclone) is used to treat insomnia in people over the age of 18. This medication can help you fall asleep faster and wake up fewer times during the night. Lunesta (eszopiclone) belongs to a drug class called sedative-hypnotics, and it's a controlled substance so there are restrictions on how it can be filled and refilled at the pharmacy. You typically only need to take a dose right before bedtime, but it can cause a headache or leave a bad taste in your mouth as a side effect.

Indications for Lunesta

  • Insomnia (trouble falling or staying asleep)

Pros and Cons for Lunesta

Pros

  • Available as a lower-cost generic
  • Can help you fall asleep and stay asleep
  • Fewer side effects and less addicting than some other sleep medications

Cons

  • Can cause sedation, dizziness, and poor coordination the next day, especially at higher doses
  • Can lead to rebound insomnia after stopping the medication, especially if you've taken it for a long time
  • Risk of abnormal sleep behaviors, such as sleepwalking or sleep driving

Common Side Effects for Lunesta

Warnings for Lunesta

  • Abnormal sleep behaviors
  • Poor mental alertness
  • Behavior changes and abnormal thinking
  • Severe allergic reactions
  • Follow up with provider to check for other reasons for insomnia
  • Withdrawal
  • Use with caution in older adults and people with certain health conditions

Summary for Butisol

Discontinued

Butisol (butabarbital) is a fast-acting sleep medication. It's not a first choice treatment option and has been discontinued. Both brand and generic options are no longer available in the U.S.

Pros and Cons for Butisol

Pros

Cons

Prices with our coupons for Lunesta vs. Butisol

Price Card Drug Icon
Eszopiclone30 tablets / 3mg
$12.67$211.86
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Price Card Drug Icon
Butisol30 tablets / 30mg
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