Key takeaways
Acetaminophen/dextromethorphan/phenylephrine (Dayquil) and acetaminophen (Tylenol) are both over-the-counter medications used to relieve symptoms like pain and fever. However, they belong to different medication classes and have distinct uses. Dayquil is a combination medication that also includes a cough suppressant and a decongestant, making it helpful for cold and flu symptoms such as cough, sore throat, and nasal congestion. On the other hand, acetaminophen is a single-ingredient analgesic used primarily for mild pain and fever. While both medications are available in oral forms, acetaminophen also comes in rectal and injectable forms. Dayquil is typically taken every 4 hours, whereas acetaminophen can be taken every 4 to 6 hours depending on the formulation. Common side effects of Dayquil include stomach upset and nervousness, while acetaminophen generally has fewer side effects but can cause nausea and headache. Because both medications contain acetaminophen, you should avoid drinking alcohol or taking other acetaminophen products while taking either medication.
