Key takeaways
Citalopram (Celexa) and escitalopram (Lexapro) are both selective serotonin reuptake inhibitors (SSRIs) used to treat depression. They work by increasing serotonin levels in the brain to help improve mood. However, there are some differences between the two medications. Citalopram (Celexa) is only FDA-approved for treating depression in adults, while escitalopram (Lexapro) is approved for both depression and generalized anxiety disorder (GAD) in adults and children. Citalopram is typically started at 20 mg once daily, with a maximum dose of 40 mg, whereas escitalopram usually starts at 10 mg once daily, with a maximum of 20 mg. Both medications are available in tablet and liquid forms, but escitalopram is available in both brand and generic forms, while citalopram is available as a generic. Common side effects for both include nausea and trouble sleeping, but escitalopram may cause more headaches, while citalopram may lead to more dry mouth. Both medications can interact with other drugs that affect serotonin levels or heart rhythm, and they can cause withdrawal symptoms if stopped suddenly.
