Key takeaways
Amoxicillin/clavulanate (Augmentin) and doxycycline hyclate (Vibramycin, Doryx) are both antibiotics used to treat bacterial infections, including sinus infections and urinary tract infections (UTIs). However, they belong to different medication classes. Amoxicillin-clavulanate is a penicillin antibiotic combined with a beta-lactamase inhibitor, while doxycycline hyclate is a tetracycline antibiotic. Amoxicillin-clavulanate is available in tablets, chewable tablets, and liquid suspensions, and is typically taken two to three times daily. Doxycycline hyclate comes in capsules, tablets, and liquid syrup, and is usually taken once or twice daily. Both medications are available as lower-cost generics. Common side effects of amoxicillin-clavulanate include diarrhea, nausea, and rash, whereas doxycycline hyclate can cause stomach upset, nausea, and increased sensitivity to sunlight. Amoxicillin-clavulanate interacts with medications like warfarin, while doxycycline hyclate can interact with blood thinners and birth control pills.
