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Codeine

Codeine Side Effects

Robert Chad Hakim, PharmD, BCCCPConnie Zheng, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Connie Zheng, PharmD
Last reviewed on March 20, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Sleepiness
  • Lightheadedness
  • Dizziness
  • Trouble breathing
  • Nausea
  • Vomiting
  • Sweating
  • Constipation

Less Common Side Effects

  • Itching
  • Stomach pain

Codeine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
  • Accidentally taking too much (overdose): not responding to sound or touch, slowed breathing, extreme sleepiness, slow heartbeat, cold or clammy skin
  • Opioid withdrawal: anxiety, suicidal thoughts, irritability, restlessness, runny nose, yawning, sweating, chills, wide pupils
  • Serious allergic reaction: itchy, red rash (hives); difficulty breathing; chest tightness; swelling of lips, tongue, throat, face, or eyes
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The following Codeine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Bloating

blurred vision

chills

cold, clammy skin

confusion

constipation

darkened urine

difficult or troubled breathing

dizziness

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fainting

fast, irregular, pounding, or racing heartbeat or pulse

fast, weak pulse

feeling of warmth

fever

indigestion

irregular, fast or slow, or shallow breathing

lightheadedness

loss of appetite

nausea

no blood pressure or pulse

no breathing

pains in the stomach, side, or abdomen, possibly radiating to the back

pale or blue lips, fingernails, or skin

redness of the face, neck, arms, and occasionally, upper chest

stopping of the heart

sweating

unconsciousness

unusual tiredness or weakness

vomiting

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Bluish lips or skin

chest pain or discomfort

constricted, pinpoint, or small pupils (black part of the eye)

decreased awareness or responsiveness

extreme sleepiness or unusual drowsiness

slow or irregular heartbeat

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Drowsiness

relaxed and calm feeling

Incidence not known

Diarrhea

disturbed color perception

double vision

dry mouth

false or unusual sense of well-being

fear or nervousness

feeling of constant movement of self or surroundings

halos around lights

headache

hives or welts, itching, or skin rash

night blindness

overbright appearance of lights

redness of the skin

sensation of spinning

shakiness

stomach pain or cramps

trouble sleeping

tunnel vision

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Connie Zheng, PharmD, is a drug information pharmacist at GoodRx and a licensed pharmacist in California. She has over 6 years of experience working in independent pharmacies.

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