Skip to main content
Nucynta

Nucynta Side Effects

Robert Chad Hakim, PharmD, BCCCPAllison Gourley, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Allison Gourley, PharmD
Last reviewed on November 18, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Immediate-release:

  • Nausea (30%)
  • Dizziness (24%)
  • Vomiting (18%)
  • Sleepiness (15%)
  • Constipation (8%)

Extended-release:

  • Nausea (21%)
  • Constipation (17%)
  • Dizziness (17%)
  • Headache (15%)
  • Sleepiness (12%)
  • Fatigue (9%)
  • Vomiting (8%)

Less Common Side Effects

  • Dry mouth
  • Upset stomach or indigestion
  • Poor appetite
  • Itching
  • Sweating
  • Anxiety
  • Difficulty sleeping
  • Tremor or shakiness

Nucynta serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
  • Accidentally taking too much (overdose): not responding to sound or touch, slowed breathing, slow heartbeat, extreme sleepiness, cold or clammy skin
  • Opioid withdrawal: anxiety, suicidal thoughts, restlessness, irritability, runny nose, yawning, sweating, chills, wide pupils
  • Serious allergic reaction: itchy, red rash (hives); shortness of breath; chest tightness; swelling of lips, tongue, throat, face, or eyes
When do Nucynta possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Nausea or vomiting
Sleepiness
Constipation
Risk for dangerously slow breathing
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

More on Nucynta side effects

A man feels nauseous.
ridvan_celik/iStock via Getty Images Plus
9 Opioid Side Effects You Should Know About
Written by Austin Ulrich, PharmD, BCACP

The following Nucynta side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Bladder pain

bloody or cloudy urine

body aches or pain

chills

cough

difficult, burning, or painful urination

difficulty with breathing

fever

headache

loss of voice

lower back or side pain

muscle aches

unusual tiredness or weakness

Rare

Anxiety

being forgetful or confused

clumsiness or unsteadiness

drowsiness

fast or irregular heartbeat

feeling drunk

irritability or restlessness

joint pain, stiffness, or swelling

pale or blue lips, fingernails, or skin

rash, hives, or itching

seizures

sensation of heaviness

shakiness or trembling

slurred speech

swelling of the eyelids, face, lips, hands, or feet

tightness in the chest

trouble with speaking or hoarseness

troubled swallowing

Incidence not known

Agitation

changes in behavior

confusion

darkening of the skin

diarrhea

dizziness

fainting

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals

loss of appetite

mental depression

nausea

overactive reflexes

poor coordination

seeing, hearing, or feeling things that are not there

shivering

sweating

talking or acting with excitement you cannot control

thoughts of killing oneself

trembling or shaking

twitching

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Constipation

Less common

Abnormal dreams

heartburn or indigestion

muscle pain or stiffness

redness of the face, neck, arms, and occasionally, upper chest

stomach discomfort, upset, or pain

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Rare

Change in vision

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

why trust our exports reliability shield

Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.

Was this page helpful?