The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Less Common Side Effects
- Dry mouth
- Upset stomach or indigestion
- Poor appetite
- Itching
- Sweating
- Anxiety
- Difficulty sleeping
- Tremor or shakiness
Nucynta serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
- Accidentally taking too much (overdose): not responding to sound or touch, slowed breathing, slow heartbeat, extreme sleepiness, cold or clammy skin
- Opioid withdrawal: anxiety, suicidal thoughts, restlessness, irritability, runny nose, yawning, sweating, chills, wide pupils
- Serious allergic reaction: itchy, red rash (hives); shortness of breath; chest tightness; swelling of lips, tongue, throat, face, or eyes
Source: DailyMed
More on Nucynta side effects

The following Nucynta side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Bladder pain
bloody or cloudy urine
body aches or pain
chills
difficult, burning, or painful urination
difficulty with breathing
headache
loss of voice
lower back or side pain
muscle aches
unusual tiredness or weakness
Rare
being forgetful or confused
clumsiness or unsteadiness
drowsiness
fast or irregular heartbeat
feeling drunk
irritability or restlessness
joint pain, stiffness, or swelling
pale or blue lips, fingernails, or skin
seizures
sensation of heaviness
shakiness or trembling
slurred speech
swelling of the eyelids, face, lips, hands, or feet
tightness in the chest
trouble with speaking or hoarseness
troubled swallowing
Incidence not known
Agitation
changes in behavior
confusion
darkening of the skin
dizziness
fainting
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
loss of appetite
mental depression
overactive reflexes
poor coordination
seeing, hearing, or feeling things that are not there
shivering
sweating
talking or acting with excitement you cannot control
thoughts of killing oneself
trembling or shaking
twitching
vomiting
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Abnormal dreams
heartburn or indigestion
muscle pain or stiffness
redness of the face, neck, arms, and occasionally, upper chest
stomach discomfort, upset, or pain
unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
Rare
Change in vision
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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