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Levorphanol

Levorphanol Side Effects

Robert Chad Hakim, PharmD, BCCCPKristianne Hannemann, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Kristianne Hannemann, PharmD
Last reviewed on March 16, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Sleepiness
  • Feeling tired
  • Headache
  • Dizziness
  • Constipation
  • Nausea
  • Vomiting
  • Stomach pain

Less Common Side Effects

  • Upset stomach or indigestion
  • Dry mouth
  • Sweating
  • Irregular heartbeat
  • Feeling nervous
  • Changes to vision
  • Itching
  • Rash
  • Difficulty urinating

Levorphanol serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
  • Accidentally taking too much (overdose): not responding to sound or touch, slowed breathing, extreme sleepiness, slow heartbeat, cold or clammy skin
  • Opioid withdrawal: anxiety, suicidal thoughts, irritability, restlessness, runny nose, yawning, sweating, chills, wide pupils
  • Serious allergic reaction: hives; shortness of breath; chest tightness; swelling of lips, tongue, throat, face, or eyes
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Source: DailyMed

The following Levorphanol side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Agitation

attempts at killing oneself

bluish lips or skin

blurred vision

change in consciousness

cold, clammy skin

confusion

darkening of the skin

decrease in the frequency of urination

decreased awareness or responsiveness

decreased urine output

depression

diarrhea

difficulty in passing urine (dribbling)

difficulty swallowing

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

extra heartbeat

extremely shallow or slow breathing

fast, slow, irregular, pounding, or racing heartbeat or pulse

fast, weak pulse

fever

hostility

hives or welts, itching, skin rash

lightheadedness

loss of appetite

loss of consciousness

muscle twitching

nausea

no blood pressure or pulse

not breathing

overactive reflexes

painful urination

poor coordination

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid weight gain

restlessness

seizures

severe sleepiness

shivering

stopping of the heart

sweating

swelling of the face, ankles, or hands

talking or acting with excitement you cannot control

tightness in the chest

trembling or shaking

twitching

unusual drowsiness, dullness, tiredness, weakness or feeling of sluggishness

vomiting

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Chest pain or discomfort

constricted, pinpoint, or small pupils (black part of the eye)

decreased awareness or responsiveness

difficult or troubled breathing

difficulty with sleeping

dilated neck veins

disorientation

drowsiness to profound loss of consciousness

extreme tiredness or weakness

headache

irregular, fast or slow, or shallow breathing

no muscle tone or movement

not breathing

pale or blue lips, fingernails, or skin

seeing, hearing, or feeling things that are not there

sleepiness or unusual drowsiness

swelling of the face, fingers, feet, or lower legs

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Abnormal dreams

absence of or decrease in body movement

belching

change in personality

changes in vision

discouragement

double vision

dry mouth

false beliefs that cannot be changed by facts

feeling sad or empty

heartburn

increase in body movements

indigestion

irritability

loss of interest or pleasure

loss of memory

nervousness

poor insight and judgment

problems with memory or speech

redness of the skin

seeing double

stomach discomfort, upset, or pain

sweating

trouble concentrating

trouble recognizing objects

trouble sleeping

trouble thinking and planning

trouble walking

twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs

upper abdominal or stomach pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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