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Fentanyl Buccal

Fentanyl Buccal Side Effects

Shifali Patel, PharmDKristianne Hannemann, PharmD
Reviewed by Shifali Patel, PharmD, Kristianne Hannemann, PharmD
Last reviewed on February 22, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea (29%)
  • Vomiting (20%)
  • Tiredness (16%)
  • Dizziness (13%)
  • Low red blood cells (13%)
  • Constipation (12%)
  • Swelling of arms or legs (12%)
  • Weakness (11%)
  • Dehydration (11%)
  • Headache (10%)
  • Application site reaction (pain, ulcer, irritation, 10%)

Less Common Side Effects

  • Drowsiness
  • Low white blood cells
  • Diarrhea
  • Stomach pain
  • Low potassium levels
  • Pneumonia
  • Weight loss
  • Low appetite
  • Confusion
  • Depression
  • Trouble sleeping
  • Shortness of breath
  • Cough

Fentanyl Buccal serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Overdose: not responding to sound or touch, slowed breathing, sleepiness, muscle weakness, small pupils, cold or clammy skin, slow heart rate, coma
  • Serious allergic reaction: hives, shortness of breath, chest tightness, swelling of lips, tongue, face, or eyes
  • Slowed breathing
  • Withdrawal in newborn babies: irritability, overactivity, abnormal sleeping pattern, excessive or high-pitched crying, body shaking (tremor), vomiting, diarrhea, poor weight-gain, breathing problems, fever, sweating, seizures
  • Adrenal insufficiency (low cortisol levels): nausea, vomiting, stomach pain, low appetite, tiredness, weakness, dizziness, low blood pressure
  • Withdrawal: restlessness, runny nose, yawning, sweating, chills, widened pupils, irritability, anxiety, suicidal thoughts

Source: DailyMed

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