Melanin synthesis inhibitor / retinoid / corticosteroid combinations are used to treat certain skin conditions that cause discoloration. These medications work by combining three types of ingredients: melanin synthesis inhibitors to reduce pigment production, retinoids to promote skin cell turnover, and corticosteroids to reduce inflammation. These combinations are typically available in topical forms, such as creams. An example is fluocinolone/hydroquinone/tretinoin (Tri-Luma). You apply these creams directly to the affected areas to help improve your skin.