GABA-agonists are used to treat insomnia and muscle spasticity. GABA-agonists work by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter (chemical messenger) that helps calm your nervous system. These medications come in different forms, including oral tablets and injectable solutions. Examples include zolpidem (Ambien, Edluar, Ambien CR), eszopiclone (Lunesta), and baclofen (Fleqsuvy, Gablofen, Lioresal, Ozobax DS).