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Cinvanti Coupon - Cinvanti 18ml of 130mg/18ml vial

Cinvanti

aprepitant
Used for Chemotherapy Side Effects
Used for Chemotherapy Side Effects

Cinvanti (aprepitant) is an injectable medication used to prevent nausea and vomiting caused by certain anti-cancer medications (chemotherapy). It's given by a healthcare provider intravenously (IV), which means the medication is delivered directly into your vein. Typically you'll only receive Cinvanti (aprepitant) on day 1 of your chemotherapy cycle. Common side effects include diarrhea and low energy. Rarely, Cinvanti (aprepitant) can also cause severe allergic reactions, such as swelling, itching, and rash. Your provider will monitor these symptoms during your treatment.

Reviewed by:
reviewer
Ally Tsai, PharmD
reviewer
Kristianne Hannemann, PharmD
Last reviewed on August 21, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageContraindicationsAlternativesImagesReferencesPricesMedicare
basics-icon

What is Cinvanti (aprepitant)?

What is Cinvanti (aprepitant) used for?

  • Prevention of nausea and vomiting caused by certain anti-cancer (chemotherapy) medications

How Cinvanti (aprepitant) works

Cinvanti (aprepitant) is an antiemetic called NK1 receptor antagonists. It works by blocking certain chemicals in the brain that can cause nausea and vomiting. In doing so, Cinvanti (aprepitant) helps ease both acute and delayed nausea and vomiting.

Are you looking for information on oral aprepitant (Emend) or injectable aprepitant (Aponvie) instead?

Drug Facts

Common BrandsCinvanti
Drug ClassNK1 receptor antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Cinvanti (aprepitant)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Tiredness (15%)
  • Diarrhea (13%)
  • Low white blood cell count (8%)
  • Low energy (4%)
  • Low red blood cell count (3%)
  • Nerve pain (3%)
Please note: These side effects were reported by adults receiving fosaprepitant (a prodrug of aprepitant) along with ondansetron and dexamethasone.

Other Side Effects

  • Pain in arms and legs
  • Indigestion
  • Urinary tract infection
  • Infusion site reaction, including pain and skin irritation

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reaction: trouble breathing, rash, swelling of lips, tongue, or throat

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Cinvanti (aprepitant)

thumbs-up

Pros

Typically just need one dose per chemotherapy cycle

Can use in people who have liver or kidney problems

Might work well for people who didn’t see benefits with other antiemetics

Can be taken together with other antiemetics (e.g., ondansetron)

thumbs-down

Cons

Only prevents nausea and vomiting, can't treat nausea and vomiting if you already have symptoms

Not clear whether it's safe or works well in children

Can't be taken with pimozide, a medication for Tourette syndrome

Needs to be delivered into a vein, which can be less convenient than taking oral tablets

pharmacist-tips

Pharmacist tips for Cinvanti (aprepitant)

pharmacist

  • You'll typically receive Cinvanti (aprepitant) on day 1 of your chemotherapy, 30 minutes before your treatment.

    • Cinvanti (aprepitant) can sometimes cause severe allergic reactions. Your provider will monitor you for symptoms such as trouble breathing, swelling of your face, flushing, rash, hives, and dizziness during and after injection.

      • Watch out for injection site reactions such as pain, hardening, redness, or itching. In some cases, your injection site might also become swollen due to a blood clot. Tell your provider right away if you experience these symptoms.

        • Don't use this medication if you're pregnant since it contains alcohol and can cause harm to your unborn baby. If you're pregnant or thinking of getting pregnant during treatment or chemotherapy, contact your provider.

          • If you're taking hormonal birth control, make sure to also use non-hormonal birth control (e.g., condoms) as a backup method during treatment and for a month after the last dose of Cinvanti (aprepitant). This is because Cinvanti (aprepitant) can cause hormonal birth control to not work as well to prevent pregnancy.

            • Cinvanti (aprepitant) can interact with many medications. Let your provider or pharmacist know what medications you're taking, including over-the-counter products and supplements, before you start Cinvanti (aprepitant). Talk with your provider or pharmacist if you have any questions about interactions with this medication.

              faqs

              Frequently asked questions about Cinvanti (aprepitant)

              Can Cinvanti (aprepitant) relieve symptoms of nausea and vomiting?
              No, Cinvanti (aprepitant) can't treat symptoms of nausea and vomiting because it's only meant to help with preventing these symptoms. If you feel nauseous after your chemotherapy, let your provider know. Your provider can prescribe other medications to help you fight off nausea and vomiting.
              How do you receive Cinvanti (aprepitant)?
              Your provider will usually determine what's the best way for you to receive Cinvanti (aprepitant). Typically, this medication is given intravenously (IV), which means it's delivered directly into your vein. Cinvanti (aprepitant) can be given over a 2-minute period (IV push) or over a 30-minutes period (IV infusion). In a clinical study that looked at both injection rates, people who received this medication over 2 minutes had the same risk of side effects as those who received it over 30 minutes. If you have any questions about how to use Cinvanti (aprepitant), talk to your provider.
              Are aprepitant injection (Cinvanti) and oral aprepitant (Emend) the same?
              Aprepitant injection (Cinvanti) and oral aprepitant (Emend) have the same active medication and are both options to prevent chemotherapy-related nausea and vomiting. One main difference between them is how you take it. Cinvanti is injected into a vein by a healthcare provider, while Emend is taken by mouth. Another difference is who can use the medication. Cinvanti can only be used in adults, while Emend can be used in adults and children 6 months and older. A third difference is how each medication is supplied. Cinvanti is only available as a brand-name product, while Emend is available as both brand-name and generic capsules. Talk with your provider to see which medication is a better option for you.
              What's the difference between aprepitant and fosaprepitant injections?
              Cinvanti (aprepitant) and fosaprepitant (Emend) are both injectable medications used to prevent nausea and vomiting caused by chemotherapy. In fact, fosaprepitant is broken down into aprepitant in your body. In two clinical studies, both medications were shown to be bioequivalent, which means you can expect similar improvements for your condition, whether you take one or the other. One major difference between the two medications is that Cinvanti (aprepitant) is less likely to cause serious allergic and injection site reactions, such as pain, swelling, redness, and itching, compared to fosaprepitant (Emend).
              Does Cinvanti (aprepitant) make you sleepy?
              People who've received Cinvanti (aprepitant) reported feeling tiredness and lower energy as side effects. But it's not clear whether these side effects are caused by Cinvanti (aprepitant) or a result of the chemotherapy, which can also make you more tired. Make sure you don't drive a car or operate machinery until you know how Cinvanti (aprepitant) affects you. Consider arranging for someone to drive you to and from your chemotherapy.
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              What are the risks and warnings for Cinvanti (aprepitant)?

              Cinvanti (aprepitant) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Serious allergic reaction

              • Risk factor: Allergic to aprepitant

                In some rare cases, Cinvanti (aprepitant) can cause allergic reactions, which can be life-threatening. Your risk is higher if you've been allergic to medications with aprepitant (e.g., Emend) in the past. Your provider will monitor you for serious allergic reactions during and after your infusion to make sure this medication is safe for you. Watch out for signs and symptoms, such as wheezing, eye swelling, flushing, itching, and rash. Let your provider know right away if you have any of these allergic reactions.

                risk-warning

                Interactions with other medications

                Cinvanti (aprepitant) interacts with many medications. Before you receive it, make sure your provider is aware of all the other medications, vitamins, and supplements you're currently taking. They can help you check for any serious medication interactions.

                Certain medications, like ketoconazole and diltiazem (Cardizem), can raise the amount of Cinvanti (aprepitant) in your body. Taking them together can make it more likely for you to experience Cinvanti (aprepitant) side effects, such as diarrhea and fatigue. On the other hand, taking certain medications like rifampin (Rifadin) can lower the amount of Cinvanti (aprepitant) in your body and cause the medication to not work as well.

                Cinvanti (aprepitant) can also cause your body to absorb less warfarin (Coumadin), which can raise your risk of blood clots. Your provider will monitor your blood work (INR blood test), 7 to 10 days after your last treatment of Cinvanti (aprepitant), to make sure warfarin (Coumadin) is working well for you.

                Finally, Cinvanti (aprepitant) might cause certain hormonal birth controls to work less well. If you're taking hormonal birth control, make sure to also use a back-up birth control, like condoms, during treatment and for at least a month after the last dose of Cinvanti (aprepitant) or oral aprepitant (Emend).

                dosage

                Cinvanti (aprepitant) dosage forms

                Typical dosing for Cinvanti (aprepitant)

                A healthcare provider will determine your dose of Cinvanti (aprepitant) based on the chemotherapy regimen you're getting and what other anti-nausea medications you're receiving.

                The typical dose of Cinvanti (aprepitant) ranges from 100 mg to 130 mg injected through the veins on day 1 of your chemotherapy cycle. Cinvanti (aprepitant) is typically given 30 minutes before chemotherapy in a hospital or at an infusion center.

                contraindications-icon

                Cinvanti (aprepitant) contraindications

                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Cinvanti (aprepitant) will not be safe for you to take.
                alternatives

                What are alternatives to Cinvanti (aprepitant)?

                There are a number of medications that your doctor can prescribe in place of Cinvanti (aprepitant). Compare a few possible alternatives below.
                Cinvanti (aprepitant)
                Used for:

                • Prevention of nausea and vomiting caused by certain anti-cancer (chemotherapy) medications

                View Prices
                Fosaprepitant (Emend)
                Used for:

                • To prevent nausea or vomiting caused by certain chemotherapy medications

                View Prices
                Ondansetron (Zofran)
                Used for:
                $11.66 Lowest GoodRx priceView Prices
                images

                Cinvanti (aprepitant) images

                amber - CINVANTI 130mg / 18mL Emulsion for Injection
                This medicine is Amber Vial.amber - CINVANTI 130mg / 18mL Emulsion for Injection

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                References

                Best studies we found

                Heron Therapeutics, Inc. (2017). Heron Therapeutics announces U.S. FDA approval of CINVANTI™ (aprepitant) injectable emulsion for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV). Business Wire.

                Heron Therapeutics, Inc. (2022). Cinvanti- aprepitant injection, emulsion [package insert]. DailyMed.

                Navari, R.M., et al. (2019). Crossover safety study of aprepitant: 2-min injection vs 30-min infusion in cancer patients receiving emetogenic chemotherapy. OncoTargets and Therapy.

                View All References (2)

                Ottoboni, T., et al. (2018). Safety of HTX-019 (intravenous aprepitant) and fosaprepitant in healthy subjects. Future Oncology.

                Wang, D. S., et al. (2021). Effect of aprepitant for the prevention of chemotherapy-induced nausea and vomiting in women: A randomized clinical trial. Journal of the American Medical Association Network Open.

                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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