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fosaprepitant

Generic Emend

Used for Chemotherapy Side Effects

Fosaprepitant (Emend) is an injectable medication used with other medications to prevent nausea and vomiting caused by certain chemotherapy medications in adults and children 6 months and older. It's given as an intravenous (IV) infusion by a trained healthcare provider.

Reviewed by:

Kristianne Hannemann, PharmD

Connie Zheng, PharmD

Last reviewed on May 11, 2022

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What is Fosaprepitant (Emend)?

What is Fosaprepitant (Emend) used for?

To prevent nausea or vomiting caused by certain chemotherapy medications

How Fosaprepitant (Emend) works

Are you looking for information on aprepitant (Emend) capsules instead?

Drug Facts

Common BrandsEmend, Focinvez

Drug ClassAntiemetic

Controlled Substance ClassificationNot a controlled medication

Generic StatusLower-cost generic available

AvailabilityPrescription only

Frequently asked questions about Fosaprepitant (Emend)

What is fosaprepitant (Emend) used for?

Fosaprepitant (Emend) is used along with other anti-nausea medications to prevent nausea or vomiting caused by certain chemotherapy medications. But it can't be used to treat nausea or vomiting if you're already feeling nauseous.

How does fosaprepitant (Emend) work?

Fosaprepitant (Emend) is an antiemetic. It helps to prevent nausea and vomiting by blocking a chemical in the brain called substance P, which controls your vomiting reflex.

What is the dose of fosaprepitant (Emend)?

For adults, the typical dose of fosaprepitant (Emend) is 150 mg infused through the veins (IV) by a healthcare provider. It's given about 30 minutes before the start of your chemotherapy on the first day of chemotherapy treatment. For children, the dose of fosaprepitant (Emend) depends on their age and body weight, and which chemotherapy treatment your child is receiving. Your child's provider will make sure your child gets the correct dose at the right time.

What are the side effects of fosaprepitant (Emend)?

In clinical trials, the most common side effects people reported are feeling extremely tired and diarrhea, followed by low red and white blood cells, weakness, and tingling in the arms or legs. Please note that in the trials, people also received two other anti-nausea medications, dexamethasone and ondansetron (Zofran), so it's hard to know if these side effects are due to fosaprepitant (Emend) alone. As with any IV infusions, fosaprepitant (Emend) can also cause infusion site reactions, including redness, swelling, and pain.

Will fosaprepitant (Emend) interact with any of my other medications?

Fosaprepitant (Emend) can interact with many different medications, including common ones like warfarin (Coumadin) and certain birth control medications. For example, fosaprepitant (Emend) can cause birth control medications that contain hormones to not work as well, which can raise your risk for getting pregnant. If you're using this type of birth control, you'll need to use a back up birth control method, such as condoms, both during treatment and for about a month after your last dose of fosaprepitant (Emend). Another example is that fosaprepitant (Emend) can cause warfarin (Coumadin) to not work as well, which can put you at risk for blood clots. If you're taking warfarin (Coumadin), your provider might need to monitor your labs more closely. Tell your provider all of the over-the-counter and prescription medications you're taking, as well as supplements, so they can let you know if there are any interactions with fosaprepitant (Emend).

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Interactions between Fosaprepitant (Emend) and other drugs

Fosaprepitant (Emend) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Fosaprepitant (Emend). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Flibanserin
Lomitapide
Pimozide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Alfentanil
Alprazolam
Amiodarone
Atazanavir
Benzhydrocodone
Boceprevir
Bosutinib
Brexpiprazole
Buprenorphine
Carbamazepine
Ceritinib
Cilostazol
Clarithromycin
Clozapine
Cobicistat
Cobimetinib
Codeine
Colchicine
Conivaptan
Desogestrel
Dienogest
Dihydrocodeine
Diltiazem
Domperidone
Doxorubicin
Doxorubicin Hydrochloride Liposome
Dronedarone
Drospirenone
Duvelisib
Eliglustat
Enzalutamide
Eplerenone
Erythromycin
Estradiol
Ethinyl Estradiol
Ethynodiol
Etonogestrel
Fentanyl
Fluconazole
Fosnetupitant
Fosphenytoin
Gestodene
Hydrocodone
Idelalisib
Imatinib
Indinavir
Itraconazole
Ivabradine
Ivosidenib
Ketoconazole
Larotrectinib
Lefamulin
Lemborexant
Letermovir
Levonorgestrel
Lopinavir
Lorlatinib
Lumacaftor
Lurasidone
Medroxyprogesterone
Meperidine
Mestranol
Methadone
Mitotane
Naloxegol
Nefazodone
Nelfinavir
Netupitant
Nomegestrol
Norelgestromin
Norethindrone
Norgestimate
Norgestrel
Olaparib
Oxycodone
Pentazocine
Phenytoin
Piperaquine
Posaconazole
Ranolazine
Rifampin
Ritonavir
Saquinavir
Segesterone
Simeprevir
Sonidegib
St John's Wort
Sufentanil
Tacrolimus
Telaprevir
Telithromycin
Tolvaptan
Tramadol
Ubrogepant
Ulipristal
Verapamil
Voriconazole

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

How much does Fosaprepitant (Emend) cost?

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Emend (brand)

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$146.49

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Fosaprepitant (Emend) (generic)

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$146.49

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What are alternatives to Fosaprepitant (Emend)?

There are a number of medications that your doctor can prescribe in place of Fosaprepitant (Emend). Compare a few possible alternatives below.

Fosaprepitant (Emend)

Used for:

To prevent nausea or vomiting caused by certain chemotherapy medications

$146.49 Lowest GoodRx priceView Prices

Emend (aprepitant)

Used for:

Prevention of nausea and vomiting caused by certain chemotherapy; taken along with dexamethasone and a serotonin antagonist (e.g., ondansetron (Zofran))

$32.14 Lowest GoodRx priceView Prices

Ondansetron (Zofran)

Used for: