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benzocaine

Generic Benzocaine
Used for Pain

Benzocaine topical is a local anesthetic. It temporarily eases minor skin irritations and pain by blocking pain signals. Benzocaine topical is applied to the skin, typically 3 to 4 times a day; most products can be used by adults and children ages 2 years and older. You can find it over-the-counter (OTC) in many dosage forms, including spray, gel, and cream. Benzocaine topical might cause some mild burning or stinging as side effects.

Reviewed by:Last reviewed on November 14, 2023
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What is Benzocaine topical?

What is Benzocaine topical used for?

Temporary relief of pain and itching from minor skin irritations, including:

How Benzocaine topical works

Benzocaine topical is a local anesthetic. It works by blocking sodium channels in the skin, which prevents sending pain signals to the brain and feeling pain.

Drug facts

Common BrandsBoil Ease, Americaine, Chiggerex
Drug ClassLocal anesthetic
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityOver-the-counter
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Side effects of Benzocaine topical

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Benzocaine topical serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe blood problem (methemoglobinemia): seizures, loss of consciousness, fast heart beat, trouble breathing, feeling dizzy or faint, feeling tired, skin color turning blue or pale
  • Serious allergic reactions: swelling of the face, difficulty breathing, trouble speaking, throat tightening up, red and itchy rash, lightheadedness, clammy skin

Source: DailyMed

The following Benzocaine topical side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Bluish color of the fingernails, lips, skin, palms, or nail beds

Incidence not known

Blistering, burning, crusting, dryness, or flaking of the skin

cracking, itching, redness, or stinging of the skin

dark urine

difficulty with breathing

difficulty with walking

dizziness or lightheadedness

fainting

fever

headache

inability to feel hands and feet

irritability

irritation of the nose

itching, scaling, severe redness, soreness, or swelling of the skin

pale skin

rapid heart rate

red, sore eyes

shortness of breath

sore throat

unusual bleeding or bruising

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Pros and cons of Benzocaine topical

Pros

  • Available over the counter as a lower-cost generic
  • Can be applied directly to the painful area
  • Comes in many dosage forms (e.g., cream, gel, ointment, spray, swab)
  • Can be used as needed
  • Can be used in children as young as 2 years old

Cons

  • Not recommended for use over large areas of injured or blistered skin because of higher risk of side effects
  • Can cause irritation if it makes contact with the eyes
  • Generally not recommended for use for longer than 1 week, unless directed by your provider
  • Young children and older adults have a higher risk of a serious blood condition from this medication.
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Pharmacist tips for Benzocaine topical

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  • There are several strengths and forms of benzocaine topical. Additionally, there are different benzocaine topical products used for different parts of the body. Make sure to carefully read the medication label of your benzocaine topical product and ask your pharmacist or provider if you have any questions.
  • It's not recommended to use more than one medication containing benzocaine at the same time unless your provider specifically said it was safe to do so. Doing so can raise your risk for side effects.
  • Don't use any kind of benzocaine topical product in children under 2 years old. Young children are at a higher risk of getting serious side effects from this medication. Ask your child's provider for safer options.
  • Avoid using benzocaine topical in or around your eyes. If you accidentally get it in your eyes, go to the hospital or contact the Poison Control Center by calling 1-800-222-1222.
  • If you're using the benzocaine topical spray, shake the canister well. Then, hold it 6 to 12 inches away from the treatment area when applying.
  • The contents of the benzocaine topical spray are under pressure. Don't use it near fire, expose it to high heat, or puncture the container. This could cause serious harm to you.
  • Wash your hands well with soap and water after using benzocaine topical. This will help avoid accidentally getting any of the medication in your eyes or mouth, which can cause irritation and other side effects.
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Risks and warnings for Benzocaine topical

Benzocaine topical can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Blood problems (methemoglobinemia)

  • Risk factors: Breathing problems | Heart disease | Certain genetic conditions | Older adults | Children under 2 years old | Smoking | Taking medications or foods containing nitrates

Benzocaine topical can cause a rare, but serious, condition known as methemoglobinemia where your blood can't get enough oxygen to your body. The signs of this reaction are headaches, dizziness, trouble breathing, fast heart rate, feeling tired, and pale, gray- or blue-colored skin, lips, and nail beds. The risk is higher in young children, older adults, and people with heart or breathing problems. Signs of methemoglobinemia can happen within minutes to one or two hours after using benzocaine topical. This reaction can develop after using the medication for the first time or even if you've used it previously. Contact your provider right away if you notice any of these symptoms after using benzocaine topical.

Serious allergic reaction to topical pain medications

Don't take benzocaine topical if you have a history of allergy to topical pain medications, such as procaine, bupivacaine, topical lidocaine. Watch out for signs and symptoms of allergic reactions, such as hives, trouble breathing, swelling of your face, lips, or throat. Please get medical attention right away if you have these signs and symptoms.

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Benzocaine topical dosage

The average cost for 1 tube of 28g of 20% of Benzocaine topical is $7.85 with a free GoodRx coupon. This is 20.63% off the average retail price of $9.89.
tube of ointmentTube of ointment
DosageQuantityPrice as low asPrice per unit
28g of 20%1 tube$7.85$7.85
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Interactions between Benzocaine topical and other drugs

Benzocaine topical may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Benzocaine topical. Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Hyaluronidase
  • St John's Wort
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How much does Benzocaine topical cost?

To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Benzocaine topical (generic)
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$7.85

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Benzocaine topical contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Benzocaine topical will not be safe for you to take.

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What are alternatives to Benzocaine topical?

There are a number of medications that your doctor can prescribe in place of Benzocaine topical. Compare a few possible alternatives below.
Benzocaine topical
Used for:

Temporary relief of pain and itching from minor skin irritations, including:

$7.85Lowest GoodRx priceView prices
Used for:

Topical lidocaine products come in many forms and strengths. Each can be used for different conditions.

In general, they're used for temporary relief of pain, itching, burning, or discomfort from:

  • Minor burns
  • Sunburns
  • Minor cuts
  • Scrapes
  • Insect bites
  • Minor skin irritations
  • Joint and muscle pain
  • Hemorrhoids and other irritations in the anal area
  • Tattoos, piercings, microblading, and other skin procedures
$5.81Lowest GoodRx priceView prices
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News about Benzocaine topical

References

Best studies we found

Bellus Medical, LLC. (2023). Benzocaine- benzocaine gel [package insert]. DailyMed.

Beutlich Pharmaceuticals, LLC. (2023). Hurricaine topical anesthetic- benzocaine spray [package insert]. DailyMed.

Centura Pharmaceuticals Inc. (2024). BLT 1- benzocaine ointment [package insert]. DailyMed.

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