The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Diarrhea (up to 62%)
- Fatigue (up to 53%)
- High blood pressure (up to 50%)
- Higher liver enzymes in the blood (up to 50%)
- Muscle and bone pain (up to 40%)
- Nausea (up to 34%)
- Lower appetite (up to 26%)
- Rash (up to 25%)
- Low thyroid hormone levels (hypothyroidism, up to 25%)
- Cough (up to 23%)
- Shortness of breath (up to 23%)
- Infusion-related reaction (up to 22%)
- Stomach pain (up to 22%)
- Headache (up to 21%)
Note: Side effects from treatment depend on what other medications you’re taking for your cancer. Bavencio (avelumab) is sometimes given along with other anticancer medications.
Less Common Side Effects
- Swelling in arms, legs, or feet
- Hand-foot syndrome
- Mouth sores
- Hoarse voice
- Urinary tract infection
Bavencio serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Immune-related side effects: cough, shortness of breath, chest pain, rash, diarrhea, stomach pain, mucus or blood in stool
- Serious infusion reactions: trouble breathing, itching, hives, flushing, swelling, chest pain, fast heartbeat, dizziness, fainting
- Heart problems: shortness of breath; swelling in hands, feet, and ankles; new chest pain; feeling dizzy or lightheaded; pain in your arms, neck, or back
Source: DailyMed
The following Bavencio side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Dry cough, shortness of breath or trouble breathing
- Eye pain, redness, irritation, or discharge with blurry or decreased vision
- Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
- Heart muscle inflammation—unusual weakness or fatigue, shortness of breath, chest pain, fast or irregular heartbeat, dizziness, swelling of the ankles, feet, or hands
- Hormone gland problems—headache, sensitivity to light, unusual weakness or fatigue, dizziness, fast or irregular heartbeat, increased sensitivity to cold or heat, excessive sweating, constipation, hair loss, increased thirst or amount of urine, tremors or shaking, irritability
- Infusion reactions—chest pain, shortness of breath or trouble breathing, feeling faint or lightheaded
- Kidney injury (glomerulonephritis)—decrease in the amount of urine, red or dark brown urine, foamy or bubbly urine, swelling of the ankles, hands, or feet
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Pain, tingling, or numbness in the hands or feet, muscle weakness, change in vision, confusion or trouble speaking, loss of balance or coordination, trouble walking, seizures
- Rash, fever, and swollen lymph nodes
- Redness, blistering, peeling, or loosening of the skin, including inside the mouth
- Sudden or severe stomach pain, bloody diarrhea, fever, nausea, vomiting
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Bone, joint, or muscle pain
- Diarrhea
- Fatigue
- Loss of appetite
- Nausea
- Skin rash
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