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Avandia

rosiglitazone
Used for Diabetes Type 2

Avandia (rosiglitazone) is an add-on medication to diet and exercise to control blood sugar in people with type 2 diabetes.

Reviewed by:Last reviewed on May 31, 2021
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What is Avandia (rosiglitazone)?

What is Avandia (rosiglitazone) used for?

  • Type 2 diabetes

How Avandia (rosiglitazone) works

Avandia (rosiglitazone) is a thiazolidinedione that improves your body's ability to use insulin to lower your blood sugar.

Drug facts

Common BrandsAvandia
Drug ClassThiazolidinedione
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Side effects of Avandia (rosiglitazone)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Respiratory infection (like a common cold) (10%)
  • Headache (6%)
  • Swelling (edema) (5%)
  • Anemia (lowering of red blood cells) (2%)

Less Common Side Effects

  • Low blood sugar
  • Weight gain
  • Fracture (broken bone)
  • Changes in liver enzymes

Avandia (rosiglitazone) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reaction
  • Worsening heart failure (shortness of breath, unusual swelling and tiredness, and sudden weight gain)
  • Diabetic eye disease with swelling (also called macular edema)
  • Liver problems (nausea or vomiting, stomach pain, unusual tiredness, loss of appetite, dark urine, yellowing of your skin or the whites of your eyes)

Source: FDA

The following Avandia (rosiglitazone) side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Abdominal or stomach pain

blurred vision

chest pain or discomfort

decrease in the amount of urine

dry mouth

flushed, dry skin

fruit-like breath odor

increased hunger

increased thirst

increased urination

irregular heartbeat

nausea

noisy, rattling breathing

pain in the shoulders, arms, jaw, or neck

pale skin

rapid or unusual weight gain

sweating

swelling of the fingers, hands, feet, or lower legs

trouble breathing

unexplained weight loss

unusual bleeding or bruising

unusual tiredness or weakness

vomiting

Rare

Anxiety

chills

cold sweats

coma

confusion

dark urine

depression

dizziness

fast heartbeat

headache

loss of appetite

nightmares

seizures

shakiness

slurred speech

Incidence not known

Blue lips and fingernails

changes in vision

coughing that sometimes produces a pink frothy sputum

hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

itching or skin rash

light-colored stools

redness of the skin

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Ear congestion

fever

general feeling of discomfort or illness

hoarseness or other voice changes

injury

joint pain

muscle aches and pains

runny or stuffy nose

shivering

sneezing

sore throat

trouble sleeping

Less common

Back pain

cough

diarrhea

lightheadedness

pain or tenderness around the eyes and cheekbones

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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$144.990
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Pros and cons of Avandia (rosiglitazone)

Pros

  • Prevents the harmful effects of high sugar levels on your organs
  • Rarely causes dangerously low blood sugar on its own
  • Can be taken with or without food
  • Can be used together with other diabetes medications

Cons

  • Not recommended as a first-choice drug for lowering blood sugar
  • Might cause weight gain
  • Might not be good for people with heart or liver problems
  • Has chance of raising your risk of heart attacks
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Pharmacist tips for Avandia (rosiglitazone)

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  • Sexually active women who take Avandia (rosiglitazone) can get pregnant, even if they don't have monthly periods. If you haven't gone through menopause, talk to your provider about birth control while taking this medication.
  • It can take up to 3 months to see the full effect of Avandia (rosiglitazone) so it's important that you continue taking the medication as instructed by your healthcare provider.
  • You can take Avandia (rosiglitazone) with or without food.
  • Maintain a healthy diet and regular exercise while on this medication to also help control your blood sugars.
  • Avandia (rosiglitazone) might cause weight gain. If you notice you've suddenly gained weight, have trouble breathing, or notice swelling in your ankles, talk to your healthcare provider right away since this could be a serious side effect.
  • Continue to monitor your hemoglobin A1C while taking Avandia (rosiglitazone) to check how well your blood sugar is controlled with Avandia (rosiglitazone).
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Risks and warnings for Avandia (rosiglitazone)

Avandia (rosiglitazone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Heart Failure

  • Risk factors: Heart failure

Black Box Warning Avandia (rosiglitazone) can cause fluid buildup that can cause or worsen heart failure. If you have advanced heart failure, talk to your provider since Avandia (rosiglitazone) may not be the best medication for you. Your provider will check your heart regularly while you're taking Avandia (rosiglitazone).

Fluid Buildup

  • Risk factors: Higher dose of Avandia (rosiglitazone)

Avandia (rosiglitazone) can cause fluid to build up in your body. This can cause heart failure if it's not caught in time. The risk is greater with a higher dose. Tell your provider about any unexpected or sudden weight gain, swelling in your arms or legs, or trouble breathing.

Liver Damage

  • Risk factors: Current liver problems

If you've had liver problems or damage in the past, talk to your provider before starting Avandia (rosiglitazone), since there's a small chance that it can hurt your liver. Tell your provider about any stomach pain that doesn't go away, dark urine, or yellowing of eyes/skin. Your provider will check your liver regularly.

Bone Fracture

  • Risk factors: Women | Osteoporosis

In some studies, women taking Avandia (rosiglitazone) were more likely to have bone fractures. If you're at risk because you already have weak bones or osteoporosis, talk to your provider about how to keep your bones healthy.

Low Blood Sugar

Taking Avandia (rosiglitazone) can cause you to have low blood sugar. This is more likely to happen if you're taking other medications that also lower your blood sugar. Talk to your healthcare provider or pharmacist about the signs of low blood sugar and how to treat it. Your healthcare provider might have to change the doses of your other medications.

Greater Risk of Heart Attack

In clinical studies, Avandia (rosiglitazone) was linked to a greater risk of heart attacks in some people. Talk to your healthcare provider to discuss this risk.

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Avandia (rosiglitazone) dosage

The average cost for 30 tablets of 4mg of Avandia (rosiglitazone) is $211.92 with a free GoodRx coupon. This is 0.00% off the average retail price of $211.92.
tabletTablet
DosageQuantityPrice as low asPrice per unit
4mg30 tablets$211.92$7.06
2mg30 tablets$144.99$4.83
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Interactions between Avandia (rosiglitazone) and other drugs

Avandia (rosiglitazone) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Avandia (rosiglitazone). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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How much does Avandia (rosiglitazone) cost?

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