Commonly Used Brand Name(s)Agrylin
Therapeutic ClassificationsPlatelet Reducing Agent
This medicine is available only with your doctor's prescription.
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Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for side effects.
You may take this medicine with or without food.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (capsules):
- For thrombocythemia:
- Adults—At first, 0.5 milligram (mg) 4 times a day or 1 mg 2 times a day for at least 1 week. Your doctor may adjust your dose as needed.
- Children—At first, 0.5 mg per day. Your doctor may adjust your dose as needed.
- For thrombocythemia:
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Use & StorageTOP
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of anagrelide in children.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of anagrelide in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Alipogene Tiparvovec
- Amtolmetin Guacil
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Choline Salicylate
- Dabigatran Etexilate
- Ethinyl Estradiol
- Flufenamic Acid
- Inotuzumab Ozogamicin
- Mefenamic Acid
- Niflumic Acid
- Nimesulide Beta Cyclodextrin
- Peginterferon Alfa-2b
- Protein C
- Salicylic Acid
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- Sodium Salicylate
- Tiaprofenic Acid
- Tolfenamic Acid
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Other Medical ProblemsTOP
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Bleeding problems or
- Congestive heart failure, history of or
- Heart disease, history of or
- Heart rhythm problems (eg, congenital long QT syndrome, QT prolongation) or
- Hypokalemia (low potassium in the blood) or
- Hypotension (low blood pressure) or
- Kidney disease or
- Lung disease (eg, interstitial lung disease), history of—Use with caution. May make these conditions worse.
- Liver disease, mild or moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
- Liver disease, severe—Should not be used in patients with this condition.
It is very important that your doctor check the progress of you or your child at regular visits to make sure that this medicine is working properly. Blood tests are needed to check for unwanted effects. You will also need to have an ECG test (electrocardiogram) to check your heart rhythm.
This medicine may cause unwanted effects on the heart. Check with your doctor right away if you or your child have chest pain, tightness, or discomfort, decreased urine output, dilated neck veins, extreme fatigue, a fast, pounding, or uneven heartbeat or pulse, pain or discomfort in the arms, jaw, back or neck, nausea or vomiting, sweating, swelling of the face, fingers, feet, or lower legs, trouble breathing, or weight gain. These could be symptoms of a serious heart problem.
This medicine may also increase your risk of bleeding. Check with your doctor immediately if you or your child notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.
This medicine may cause lung problems, including interstitial lung disease or pulmonary hypertension (high blood pressure in the lungs). These are life-threatening conditions and require immediate medical attention. The symptoms may be similar to the symptoms of lung cancer. Check with your doctor right away if you have new or worsening cough, fever, or trouble breathing.
Do not stop using this medicine suddenly without checking first with your doctor. You may need to slowly decrease your dose before stopping it completely. To do so will cause the platelet level in your blood to increase quickly.
Do not take aspirin or aspirin-containing products since they may also affect your platelets. Do not take any other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.