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Zolgensma

Zolgensma Side Effects

Yen Nguyen, PharmDAllison Gourley, PharmD
Reviewed by Yen Nguyen, PharmD, Allison Gourley, PharmD
Last reviewed on June 13, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Liver problems (high liver protein levels; 27%)
  • Vomiting (7%)

Less Common Side Effects

  • Fever

Zolgensma serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Liver failure: vomiting, right upper stomach pain, dark urine, yellow skin or eyes
  • Heart problems: changes in heart rate, bluish or grayish color of the skin, or fast or difficulty breathing
  • Thrombotic microangiopathy (TMA): fever, very high blood pressure, kidney problems, stomach pain, diarrhea, stroke, confusion, heart problems, or eye damage.

Source: DailyMed

The following Zolgensma side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Hemolytic anemia—unusual weakness or fatigue, dizziness, headache, trouble breathing, dark urine, yellowing skin or eyes
  • Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
  • Infusion reactions—chest pain, shortness of breath or trouble breathing, feeling faint or lightheaded
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Unusual bruising or bleeding

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Vomiting
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