11 Medications You Should Take on an Empty Stomach
Discover the 11 meds best taken on an empty stomach for optimal efficacy. Get the facts on dosage and timing with GoodRx.
zafirlukast
Used for Asthma
Used for Asthma
Zafirlukast (Accolate) is used to help control symptoms of asthma in people age 5 years and older. It's a tablet that you take by mouth two times every day. This medication helps improve lung function over time; it's not a rescue inhaler so it isn't used when you're having an asthma attack. The most common side effect of zafirlukast (Accolate) is headache. It's available as both a brand-name and generic medication.
What is Zafirlukast (Accolate)?
What is Zafirlukast (Accolate) used for?
- Asthma (long-term treatment)
How Zafirlukast (Accolate) works
Zafirlukast (Accolate) is a leukotriene receptor antagonist. It blocks inflammatory chemicals in your body called leukotrienes from narrowing your airways and from making too much mucus in your lungs.
Drug facts
| Common Brands | Accolate |
|---|---|
| Drug Class | Leukotriene receptor antagonist |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
Side effects of Zafirlukast (Accolate)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Headache (13%)
Less Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Stomach pain
- General pain
- Muscle or back pain
- Dizziness
- Weakness
- Fever
- Infection
Zafirlukast (Accolate) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Allergic reaction: trouble breathing; hives; rash; blisters on skin; swelling of your face, lips, or tongue
- Liver problems: upper right stomach pain, nausea, tiredness, flu-like symptoms, loss of appetite, yellowing of the skin or whites of your eyes
- Changes in mood: feeling down or hopeless, thoughts of harming yourself, trouble sleeping
- Symptoms related to high white blood cell levels: intense itching, rash, trouble breathing, worse breathing problems, tingling or numbness in hands or feet
The following Zafirlukast (Accolate) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Rare
Abdominal or stomach pain
clay-colored stools
dark urine
dizziness
headache
loss of appetite
rash
unpleasant breath odor
unusual tiredness or weakness
vomiting of blood
yellow eyes or skin
Incidence not known
Attack, assault, or force
attempts at killing oneself
discouragement
fear or nervousness
feeling sad or empty
fever with or without chills
general feeling of tiredness or weakness
hyperventilation
irregular heartbeats
irritability
lack of appetite
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
loss of interest or pleasure
restlessness
seeing, hearing, or feeling things that are not there
shakiness in the legs, arms, hands, or feet
shortness of breath
sores, ulcers, or white spots on the lips or in the mouth
tiredness
trembling or shaking of the hands or feet
trouble with concentrating
trouble with sleeping
unable to sleep
unusual bleeding or bruising
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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Pros and cons of Zafirlukast (Accolate)
Pros
- Helps control asthma symptoms in the long run
- A tablet that's taken by mouth (not an inhaler)
- Can use in children as young as 5 years old
- Available in a lower-cost generic form
Cons
- Not a first-choice option to help control asthma long-term
- Taken twice a day
- Must take at least 1 hour before or 2 hours after meals
- Not recommended if you have liver problems
Pharmacist tips for Zafirlukast (Accolate)
- Always have your rescue inhaler with you at all times to help stop an asthma attack if it happens. Zafirlukast (Accolate) works to control your asthma over time; it doesn't help treat asthma attacks.
- Take zafirlukast (Accolate) every day even if you don't have any asthma symptoms. This medication works to improve your overall lung function in the long run.
- Take zafirlukast (Accolate) on an empty stomach at least 1 hour before or 2 hours after meals. Food can affect how much medication gets absorbed into your body, which can affect how well it works.
- Don't change the dose or stop taking zafirlukast (Accolate) or any of your other asthma medications without talking to your provider first. Your asthma symptoms might come back if it's not controlled well enough.
- Make sure to tell your provider and pharmacist about all the medications you're taking or planning to take. They can check for any potentially serious interactions with zafirlukast (Accolate) and adjust your medications to keep you safe.
Risks and warnings for Zafirlukast (Accolate)
Zafirlukast (Accolate) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Not a rescue inhaler for asthma attacks
While zafirlukast (Accolate) can control your asthma in the long run, it can't stop an asthma attack that's happening. Make sure to always have your rescue inhaler with you at all times so you can use it when these attacks happen. Continue taking zafirlukast (Accolate) as instructed by your provider if you have an asthma attack.
Liver damage
- Risk factors: History of liver problems
Though rare, some people taking zafirlukast (Accolate) have had liver damage. In most cases, signs and symptoms of liver damage went away when they stopped taking the medication. But in rare cases, liver damage worsened to life-threatening liver failure. Call your provider right away if you have upper right stomach pain, nausea, tiredness, yellowing of your skin or whites of the eyes, flu-like symptoms, or loss of appetite. These can be signs of liver damage.
Depression, changes in mood, and trouble sleeping
Some people who take zafirlukast (Accolate) have reported getting depressed and having trouble sleeping. Let your provider know right away if you or your loved ones notice that you feel sad or hopeless, have lost interest in doing things that you usually enjoy, have trouble sleeping, or have other signs or symptoms of depression.
Conditions related to high levels of white blood cells
- Risk factors: Stopping or lowering the dose of an oral corticosteroid medication
Very rarely, some people taking zafirlukast (Accolate) had symptoms related to high levels of white blood cells (eosinophilia). Symptoms can include intense itching, rash, worsened breathing problems, trouble breathing, tingling or numbness in hands or feet, and pain and swelling of your sinuses. They might be more likely to happen if you're stopping or lowering the dose of an oral corticosteroid medication while you're taking zafirlukast (Accolate). Tell your provider right away if you notice any of these symptoms during treatment.
Higher risk of bleeding if taken with warfarin (Coumadin)
Taking zafirlukast (Accolate) together with the blood thinner warfarin (Coumadin) can raise your risk of bleeding. Let the provider who's managing your blood thinner medication know that you're taking zafirlukast (Accolate). They'll follow up with you more often to check for your risk of bleeding and adjust your warfarin (Coumadin) dose accordingly.
Zafirlukast (Accolate) dosage
The average cost for 60 tablets of 20mg of Zafirlukast (Accolate) is $41.15 with a free GoodRx coupon. This is 56.93% off the average retail price of $95.54.
Typical dosage for Zafirlukast (Accolate)
- Adults and children age 12 years or older: The typical dose is 20 mg by mouth twice a day.
- Children ages 5 to 11 years old: The typical dose is 10 mg by mouth twice a day.
Interactions between Zafirlukast (Accolate) and other drugs
Zafirlukast (Accolate) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Zafirlukast (Accolate). Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Erythromycin
- Terfenadine
- Theophylline
- Warfarin
How much does Zafirlukast (Accolate) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Zafirlukast (Accolate) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Zafirlukast (Accolate) will not be safe for you to take.
- Liver problems, including cirrhosis
What are alternatives to Zafirlukast (Accolate)?
There are a number of medications that your doctor can prescribe in place of Zafirlukast (Accolate). Compare a few possible alternatives below.
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Zafirlukast (Accolate) images
