Key takeaways
Zafirlukast (Accolate) and montelukast (Singulair) are both leukotriene receptor antagonists used to control asthma, but they have some key differences. Zafirlukast is taken twice a day on an empty stomach, while montelukast is taken once a day and can be taken with or without food. Montelukast is also used for treating year-round and seasonal allergies and preventing exercise-induced asthma, whereas zafirlukast is not. Montelukast is available in various forms, including chewable tablets and granules, while zafirlukast is only available as a tablet. Additionally, montelukast has been associated with serious mental health side effects, such as aggressive behavior and suicidal thoughts, which are not commonly reported with zafirlukast. Both medications are available in generic forms, making them more affordable options.
