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Vinblastine

Vinblastine Side Effects

Allison Baxley, PharmD, BCOPCydnee Ng, PharmD
Reviewed by Allison Baxley, PharmD, BCOP, Cydnee Ng, PharmD
Last reviewed on August 1, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Low white blood cells
  • Low red blood cells (anemia)
  • Low platelets
  • Hair loss
  • Constipation
  • High blood pressure
  • Feeling unwell
  • Weakness
  • Bone pain
  • Jaw pain
  • Pain where the cancer is

Less Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Poor appetite
  • Stomach pain
  • Mouth sores
  • Sore throat
  • Headache
  • Dizziness
  • Numbness in the fingers and toes
  • Irritation around the injection site

Vinblastine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious infection: temperature of 100.4ºF or higher, chills, cough, muscle aches, very fast heartbeat, confusion
  • Bleeding: nosebleeds, blood in urine, blood in stool, unexplained bruising, bleeding that doesn’t stop
When do Vinblastine possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Low white blood cells
Hair loss
Constipation
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Vinblastine side effects have also been reported

Along with their needed effects, medicines like vinblastine can sometimes cause unwanted effects such as blood problems, loss of hair, and other side effects. These and other effects are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More frequent

Cough or hoarseness accompanied by fever or chills

fever or chills

lower back or side pain accompanied by fever or chills

painful or difficult urination accompanied by fever or chills

Less common

Blood in urine or stools

pain or redness at place of injection

pinpoint red spots on skin

unusual bleeding or bruising

Rare

Black, tarry stools

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

Joint pain

sores in mouth and on lips

swelling of feet or lower legs

Rare

Difficulty in walking

dizziness

double vision

drooping eyelids

headache

jaw pain

mental depression

numbness or tingling in fingers and toes

pain in fingers and toes

pain in testicles

weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Bone or muscle pain

nausea and vomiting

This medicine often causes a temporary loss of hair. After treatment with vinblastine has ended, or sometimes even during treatment, normal hair growth should return.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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