The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Children less than 2 years old:
- Irritability (up to 63%)
- Sleepiness (up to 48%)
- Pain at injection site (up to 40%)
- Fever (up to 20%)
- Not eating well (up to 19%)
- Redness or swelling at injection site (up to 15%)
Adults and children age 2 years and older:
- Pain at injection site (up to 76%)
- Fatigue (up to 34%)
- Muscle pain (up to 29%)
- Headache (up to 27%)
- Swelling at injection site (up to 22%)
- Redness at injection site (up to 15%)
- Joint pain (up to 12%)
Less Common Side Effects
- Rash at injection site
Vaxneuvance serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reactions: hives, dizziness, fever, rash, shaking, itching, nausea, flushing, low blood pressure, shortness of breath, chest pain
Source: DailyMed
The following Vaxneuvance side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Fatigue
- Fever
- Headache
- Joint pain
- Muscle pain
- Pain, redness, or irritation at injection site


