The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Please note: The following side effects are those reported with Heplisav-B. Side effects are less likely to happen after the second dose.
- Injection site pain (35-39%)
- Fatigue (14-17%)
- Headache (13-17%)
- General feeling of sickness (7-9%)
Please note: The following side effects are those reported with PreHevbrio. Side effects are less likely to happen after the second and third dose.
- Injection site pain (27–58%)
- Tenderness (30– 59%)
- Muscle pain (12–30%)
- Fatigue (12- 28%)
- Headache (7–25%)
Less Common Side Effects
- Redness at injection site
- Swelling at injection site
- Fever
- Itching
- Nausea/Vomiting
- Diarrhea
Heplisav-B serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reactions: Hives, rash, shaking, itching, nausea, flushing, dizziness, shortness of breath, chest pain
Source: DailyMed
The following Heplisav-B side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
Fever of 37.7 degrees C (100 degrees F) or higher
Rare
Aches or pain in the joints, fever, or skin rash or welts (may occur days or weeks after receiving the vaccine)
blurred vision or other vision changes
confusion
difficulty with breathing or swallowing
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
itching, especially of the feet or hands
muscle weakness
numbness or tingling of the arms and legs
reddening of the skin, especially around the ears
sweating
swelling of the eyes, face, or inside of the nose
unusual tiredness or weakness (sudden and severe)
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Dizziness
headache
soreness at the injection site
Less common
Hard lump, redness, swelling, pain, itching, purple spot, tenderness, or warmth at the injection site
unusual tiredness or weakness
Rare
Aches or pain in the muscles
agitation
back pain or stiffness or pain in neck or shoulder
chills
difficulty with moving
feeling of warmth
general feeling of discomfort or illness
headache (mild), sore throat, runny nose, or fever (mild)
increased sweating
lack of appetite or decreased appetite
nausea or vomiting
redness of the face, neck, arms, and occasionally, upper chest
sleepiness or unusual drowsiness
stomach cramps or pain
sudden redness of skin
swelling of glands in the armpit or neck
trouble with sleeping
unable to sleep
welts
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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