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Twinrix

Twinrix Side Effects

Robert Chad Hakim, PharmD, BCCCPAllison Gourley, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Allison Gourley, PharmD
Last reviewed on January 6, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Soreness at injection site (up to 41%)
  • Headache (up to 22%)
  • Fatigue (up to 14%)
  • Redness at injection site (up to 11%)

Less Common Side Effects

  • Swelling at injection site
  • Nausea
  • Vomiting
  • Diarrhea
  • Fever

Twinrix serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious allergic reaction: hives, rash, itching, shaking, nausea, flushing, dizziness, shortness of breath, chest pain

Source: DailyMed

More on Twinrix side effects

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The following Twinrix side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Fever more than 99.5 degrees F

unusual tiredness or weakness

Rare

Difficulty with breathing or swallowing

hives

itching, especially of the hands or feet

reddening of the skin, especially around the ears

swelling of the eyes, face, or inside of the nose

unusual tiredness or weakness (sudden and severe)

Incidence not known

Agitation

back pain

being forgetful

black, tarry stools

bleeding gums

blistering, peeling, or loosening of the skin

blood in the urine or stools

bloody nose

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chills

coma

confusion

convulsions or seizures

cough

dark urine

diarrhea

difficulty controlling your bladder or bowels

difficulty with walking

dizziness

drowsiness

fast, irregular, pounding, or racing heartbeat or pulse

feeling of discomfort

feeling sad or depressed

general feeling of illness

general tiredness and weakness

hallucinations

headache

heavier menstrual periods

inability to move the arms and legs

increased sweating

inflammation of the joints

irritability

itching

joint or muscle pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

light-colored stools

muscle aches or cramps

nausea or vomiting

numbness or tingling in your arms, face, hands, or legs

partial or slight paralysis

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rash

red, irritated eyes

redness, soreness, or itching skin

severe headache

shortness of breath

slurred speech or problems with swallowing

sore throat

sores, ulcers, or white spots in the mouth or on the lips

sores, welting, or blisters

stiff neck or back

sudden numbness and weakness in the arms and legs

swollen lymph glands

tightness in the chest

unusual bleeding or bruising

unusual tiredness or weakness

upper right abdominal or stomach pain

wheezing

yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Body aches or pain

ear congestion

hard lump, redness, soreness, or swelling at the injection site

loss of voice

nasal congestion

runny nose

sneezing

Rare

Abdominal or stomach pain

bruising at the injection site

dry mouth

fainting or lightheadedness when getting up suddenly from a lying or sitting position

feeling of constant movement of self or surroundings

feeling of warmth

headache, severe and throbbing

hyperventilation

large, flat, blue or purplish patches in the skin at the injection site

loss of appetite

muscle pain or stiffness

pain, swelling, or redness in the joints

redness of the face, neck, arms, and occasionally, upper chest

restlessness

sensation of spinning

shaking

sleepiness or unusual drowsiness

sleeplessness

small, red or purple spots on the skin

sweating

trouble with sleeping

unable to sleep

unusually fast heartbeat

unusually warm skin

weakness

weight loss

Incidence not known

Acid or sour stomach

belching

continuing ringing or buzzing or other unexplained noise in the ears

disturbed color perception

double vision

earache

hair loss or thinning of the hair

halos around lights

hearing loss

heartburn

indigestion

night blindness

overbright appearance of lights

painful blisters on the trunk of the body

stomach discomfort or upset

tunnel vision

weakness of the muscles in your face

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.

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