The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Soreness at injection site (up to 41%)
- Headache (up to 22%)
- Fatigue (up to 14%)
- Redness at injection site (up to 11%)
Less Common Side Effects
- Swelling at injection site
- Nausea
- Vomiting
- Diarrhea
- Fever
Twinrix serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reaction: hives, rash, itching, shaking, nausea, flushing, dizziness, shortness of breath, chest pain
Source: DailyMed
More on Twinrix side effects

The following Twinrix side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
Rare
Difficulty with breathing or swallowing
itching, especially of the hands or feet
reddening of the skin, especially around the ears
swelling of the eyes, face, or inside of the nose
unusual tiredness or weakness (sudden and severe)
Incidence not known
Agitation
back pain
being forgetful
black, tarry stools
bleeding gums
blistering, peeling, or loosening of the skin
blood in the urine or stools
bloody nose
blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chills
coma
confusion
convulsions or seizures
dark urine
difficulty controlling your bladder or bowels
difficulty with walking
dizziness
drowsiness
fast, irregular, pounding, or racing heartbeat or pulse
feeling of discomfort
feeling sad or depressed
general feeling of illness
general tiredness and weakness
hallucinations
headache
heavier menstrual periods
inability to move the arms and legs
increased sweating
inflammation of the joints
irritability
joint or muscle pain
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
muscle aches or cramps
nausea or vomiting
numbness or tingling in your arms, face, hands, or legs
partial or slight paralysis
pinpoint red spots on the skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
rash
red, irritated eyes
redness, soreness, or itching skin
severe headache
shortness of breath
slurred speech or problems with swallowing
sores, ulcers, or white spots in the mouth or on the lips
sores, welting, or blisters
stiff neck or back
sudden numbness and weakness in the arms and legs
swollen lymph glands
tightness in the chest
unusual bleeding or bruising
unusual tiredness or weakness
upper right abdominal or stomach pain
yellow eyes and skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Body aches or pain
ear congestion
hard lump, redness, soreness, or swelling at the injection site
loss of voice
Rare
Abdominal or stomach pain
bruising at the injection site
fainting or lightheadedness when getting up suddenly from a lying or sitting position
feeling of constant movement of self or surroundings
feeling of warmth
headache, severe and throbbing
hyperventilation
large, flat, blue or purplish patches in the skin at the injection site
loss of appetite
muscle pain or stiffness
pain, swelling, or redness in the joints
redness of the face, neck, arms, and occasionally, upper chest
restlessness
sensation of spinning
shaking
sleepiness or unusual drowsiness
small, red or purple spots on the skin
sweating
trouble with sleeping
unable to sleep
unusually fast heartbeat
unusually warm skin
weakness
Incidence not known
Acid or sour stomach
belching
continuing ringing or buzzing or other unexplained noise in the ears
disturbed color perception
double vision
hair loss or thinning of the hair
halos around lights
hearing loss
indigestion
night blindness
overbright appearance of lights
painful blisters on the trunk of the body
stomach discomfort or upset
tunnel vision
weakness of the muscles in your face
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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