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Twinrix Coupon - Twinrix 1ml syringe

Twinrix

hepatitis A and hepatitis B vaccine
Used for Hepatitis B, Hepatitis A
Used for Hepatitis B, Hepatitis A

Twinrix is a vaccine that protects you from getting sick from two types of viral liver infections: hepatitis A and hepatitis B. Twinrix is only for adults who haven't been vaccinated against these two infections yet. It's injected into the shoulder muscle by a healthcare professional (HCP). Twinrix is given as either a standard 3-dose series or a 4-dose series (accelerated schedule). Common side effects include soreness, redness, and swelling at the injection site. Headache and fatigue are common, too.

Last reviewed on January 5, 2025
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What is Twinrix?

What is Twinrix used for?

How Twinrix works

Twinrix is an inactivated vaccine that protects you from the hepatitis A and hepatitis B viruses. The vaccine helps your body's immune system make antibodies that will attack either virus if they ever infect you.

Drug Facts

Common BrandsTwinrix
Drug ClassVaccine
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
$174.02(save 21.86%)
GoodRx discount
$135.99
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What are the side effects of Twinrix?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Soreness at injection site (up to 41%)
  • Headache (up to 22%)
  • Fatigue (up to 14%)
  • Redness at injection site (up to 11%)

Other Side Effects

  • Swelling at injection site
  • Nausea
  • Vomiting
  • Diarrhea
  • Fever

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reaction: hives, rash, itching, shaking, nausea, flushing, dizziness, shortness of breath, chest pain

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Fever more than 99.5 degrees F

unusual tiredness or weakness

Rare

Difficulty with breathing or swallowing

hives

itching, especially of the hands or feet

reddening of the skin, especially around the ears

swelling of the eyes, face, or inside of the nose

unusual tiredness or weakness (sudden and severe)

Incidence not known

Agitation

back pain

being forgetful

black, tarry stools

bleeding gums

blistering, peeling, or loosening of the skin

blood in the urine or stools

bloody nose

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chills

coma

confusion

convulsions or seizures

cough

dark urine

diarrhea

difficulty controlling your bladder or bowels

difficulty with walking

dizziness

drowsiness

fast, irregular, pounding, or racing heartbeat or pulse

feeling of discomfort

feeling sad or depressed

general feeling of illness

general tiredness and weakness

hallucinations

headache

heavier menstrual periods

inability to move the arms and legs

increased sweating

inflammation of the joints

irritability

itching

joint or muscle pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

light-colored stools

muscle aches or cramps

nausea or vomiting

numbness or tingling in your arms, face, hands, or legs

partial or slight paralysis

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rash

red, irritated eyes

redness, soreness, or itching skin

severe headache

shortness of breath

slurred speech or problems with swallowing

sore throat

sores, ulcers, or white spots in the mouth or on the lips

sores, welting, or blisters

stiff neck or back

sudden numbness and weakness in the arms and legs

swollen lymph glands

tightness in the chest

unusual bleeding or bruising

unusual tiredness or weakness

upper right abdominal or stomach pain

wheezing

yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Body aches or pain

ear congestion

hard lump, redness, soreness, or swelling at the injection site

loss of voice

nasal congestion

runny nose

sneezing

Rare

Abdominal or stomach pain

bruising at the injection site

dry mouth

fainting or lightheadedness when getting up suddenly from a lying or sitting position

feeling of constant movement of self or surroundings

feeling of warmth

headache, severe and throbbing

hyperventilation

large, flat, blue or purplish patches in the skin at the injection site

loss of appetite

muscle pain or stiffness

pain, swelling, or redness in the joints

redness of the face, neck, arms, and occasionally, upper chest

restlessness

sensation of spinning

shaking

sleepiness or unusual drowsiness

sleeplessness

small, red or purple spots on the skin

sweating

trouble with sleeping

unable to sleep

unusually fast heartbeat

unusually warm skin

weakness

weight loss

Incidence not known

Acid or sour stomach

belching

continuing ringing or buzzing or other unexplained noise in the ears

disturbed color perception

double vision

earache

hair loss or thinning of the hair

halos around lights

hearing loss

heartburn

indigestion

night blindness

overbright appearance of lights

painful blisters on the trunk of the body

stomach discomfort or upset

tunnel vision

weakness of the muscles in your face

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Twinrix

thumbs-up

Pros

Helps protect against both hepatitis A and hepatitis B in one vaccine

Accelerated dosing schedule available for people who need to get vaccinated quickly

Readily available at local pharmacies

thumbs-down

Cons

Only approved for adults

Only given as an injection into the muscle

Must be given by a healthcare professional at a medical office, clinic, or pharmacy

pharmacist-tips

Pharmacist tips for Twinrix

pharmacist
  • If you're traveling and haven't been vaccinated against hepatitis A or hepatitis B, ask a healthcare professional (HCP) about any travel vaccines that you need before you leave. Check whether it's recommended for you to get vaccinated with Twinrix for your destination.

    • Make sure to mark on your calendar the dates for each of your Twinrix injections (usually 3). This makes sure you become fully protected against hepatitis A and hepatitis B. Try to stay on schedule as best as possible. But contact your HCP or pharmacist if you accidentally miss a dose in the series.

      • The area where you got your Twinrix shot can get sore, red, and a little swollen for a few days. You also might feel tired and have headaches within 4 days of getting your vaccination. Contact an HCP if these side effects last longer and are severe.

        • Make sure you're feeling well when you get Twinrix. This will help make sure your immune system protects you as best as it can. You can still get your shot if you have a mild sickness, such as a cold or low-grade fever. But wait until you recover if you feel very sick. Ask your HCP if you're not sure whether or not you should get this vaccine when you're feeling under the weather.

          • It's recommended to wait at least 4 weeks after you've gotten your Twinrix dose to donate blood. You might have some of the vaccine still in your system. This can be mistaken as the virus when your donated blood gets screened for blood-borne diseases later. Your blood could get rejected from blood donation organizations.

            • Receiving Twinrix doesn't guarantee that you won't get infected with the hepatitis virus. In addition to the vaccine, take all necessary precautions while traveling to areas where hepatitis A is common to avoid getting sick from unclean food and beverages. For example, avoid raw foods, street food, bushmeat (animals not typically eaten in the United States), tap water, ice, and freshly squeezed juice.

              faqs

              Frequently asked questions about Twinrix

              How many doses of Twinrix do you need?
              You'll typically need to get 3 doses of Twinrix over a 6-month period. Another option is a 4-dose series where you receive 3 doses over a month and then a booster dose 1 year later. Keep in mind these two dosing schedule options are specific to Twinrix. Other hepatitis A or hepatitis B vaccines have different dosing schedules.
              Does Twinrix last for life?
              A study showed that people who completed Twinrix vaccination were protected from hepatitis A and hepatitis B for up to 20 years. Depending on your other medical conditions or specific situation, your healthcare professional (HCP) might test for levels of hepatitis A or B antibodies in your blood to see how well you're protected. Speak with a healthcare professional if you have more questions about how long protection lasts.
              How is Twinrix administered?
              Twinrix is given as an injection into the shoulder muscle by a healthcare professional. It's typically given as 3 injections over a 6-month period. Twinrix isn't a vaccine that you can pick up at the pharmacy and give to yourself at home. You can find Twinrix at most local pharmacies, medical offices, or travel clinics.
              Is the Twinrix vaccine live or dead?
              Twinrix is an inactivated ("dead") vaccine. The vaccine doesn't contain any live viruses, so it's safe for people with a weakened immune system. Keep in mind that people with a weakened immune system might have a lower response to Twinrix.
              Can Twinrix be given with other vaccines?
              Yes. You can receive other vaccines at the same appointment for Twinrix. Each vaccine is a separate injection. Keep in mind that you'll probably feel similar side effects at the injection site, like soreness and pain.
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              What are the risks and warnings for Twinrix?

              Twinrix can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Severe allergic reaction

              • Risk factors: Allergic reaction to other vaccines

                As with any vaccine, there's a rare chance that you might have a severe allergic reaction to Twinrix. Tell your HCP if you've had an allergic reaction to any vaccines in the past before you get Twinrix. Your HCP might ask you to stay a little longer at the pharmacy or clinic after you've received your vaccination. They can make sure you can get proper care in case of a serious allergic reaction.

                Sometimes, allergic reactions can happen after you've already left the clinic. Get medical help right away if you notice symptoms of a severe allergic reaction, such as swelling of the face, closing of the throat, difficulty breathing, hives or rash, dizziness, or chest pain.

                risk-warning

                Fainting

                • Risk factors: Fainting after vaccines in the past

                  Fainting can happen while or after receiving injectable vaccines, including Twinrix. Fainting can come along with changes in vision, burning or tingling sensation, and stiffening or twitching of your arms and legs. Let your HCP know if you've ever fainted after you've gotten vaccinated in the past so they can look after you more carefully.

                  risk-warning

                  Lower response to Twinrix in people with a weakened immune system

                  • Risk factors: Medical conditions that weaken the immune system | Taking medications that lower your immune system

                    Twinrix might not work as well in people with a weakened immune system. This can put them at higher risk of hepatitis A or B, even after they've received the vaccine.

                    Talk with your HCP first before you get Twinrix if you have any medical conditions that weaken your immune system, like human immunodeficiency virus (HIV) or cancer. Also make sure your HCP knows about the medications you take so they can check whether you're taking any medications that affect your immune system, such as high-dose corticosteroids and transplant medications.

                    More on Twinrix warnings

                    dosage

                    Twinrix dosage forms

                    The average cost for 1 syringe of 1ml of Twinrix is $135.99 with a free GoodRx coupon. This is 21.86% off the average retail price of $174.02.
                    syringe
                    Syringe
                    DosageQuantityPrice as low asPrice per unit
                    1ml1 syringe$135.99$135.99

                    Typical dosing for Twinrix

                    Each Twinrix dose is 1 injection (1 mL) given into the shoulder muscle by a healthcare professional (HCP).

                    • Typical 3-dose series: Typically, you'll get 3 injections of Twinrix over a 6-month period. After your first shot, you can get your second shot 1 month later. Then, your third shot should be about 5 months after your second shot.

                    • Accelerated schedule (4-dose series): You'll receive the 3 injections of Twinrix over 1 month with a booster dose 1 year later. After your first dose, you can get your second dose 1 week later. You should get your third dose about 2 to 3 weeks after your second dose. Then, you'll need to get a booster dose of Twinrix about 1 year from the first shot you received.

                    interactions

                    Interactions between Twinrix and other drugs

                    Twinrix may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Twinrix. Please note that only the generic name of each medication is listed below.

                    Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

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                    How much does Twinrix cost?

                    To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                    contraindications-icon

                    Twinrix contraindications

                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Twinrix will not be safe for you to take.
                    • Allergic reaction to a previous hepatitis A or hepatitis B vaccine

                    • Allergic reaction to yeast or neomycin

                    alternatives

                    What are alternatives to Twinrix?

                    There are a number of medications that your doctor can prescribe in place of Twinrix. Compare a few possible alternatives below.
                    Twinrix
                    Used for:
                    $135.99 Lowest GoodRx priceView Prices
                    Used for:
                    • Prevention of hepatitis A

                    $100.46 Lowest GoodRx priceView Prices
                    Used for:
                    • Prevention of hepatitis B in adults 18 years of age and older

                    $155.99 Lowest GoodRx priceView Prices
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                    References

                    Best studies we found

                    Centers for Disease Control and Prevention. (n.d.). Destinations.

                    Centers for Disease Control and Prevention. (2023). Food and drink considerations when traveling.

                    Centers for Disease Control and Prevention. (2024). Adult immunization schedule notes.

                    View All References (7)

                    Centers for Disease Control and Prevention. (2025). Hepatitis A prevention and control.

                    GlaxoSmithKline Biologicals SA. (2024). Twinrix (hepatitis a and hepatitis b- recombinant vaccine injection, suspension [package insert]. DailyMed.

                    Immunize.org. (2025). Ask the experts: Hepatitis B.

                    MedlinePlus. (2022). Hepatitis virus panel.

                    Nelson, N., et al. (2024). Hepatitis A. CDC Yellow Book 2024.

                    Van Damme, P., et al. (2017). Persistence of antibodies 20 y after vaccination with a combined hepatitis A and B vaccine. Human Vaccines & Immunotherapeutics.

                    World Health Organization. (2020). How do vaccines work?

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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