HEPATITIS BVACCINE reduces the risk of hepatitis B. It does not treat hepatitis B. It is still possible to get hepatitis B after receiving this vaccine, but the symptoms may be less severe or not last as long. It works by helping your immune system learn how to fight off a future infection. Get Heplisav-B for as low as $151.91, which is 19% off the average retail price of $187.81 for the most common version, by using a GoodRx coupon.