Uribel Tabs
Uribel Tabs is a combination of 5 medications used to treat pain and irritation of the urinary tract caused by lower urinary tract infections or medical procedures. Methenamine, benzoic acid, and methylene blue work together to kill or stop the growth of bacteria in the urine. Phenyl salicylate helps to ease pain. And hyoscyamine lessens the urge to urinate often or without warning. Uribel Tabs is taken by mouth, typically 4 times a day with plenty of water. It can be used by adults and children ages 6 years and older. Uribel Tabs doesn't cause many side effects, but it can sometimes cause your urine and stools to turn blue to blue-green in color; this effect is harmless and temporary.
What is Uribel Tabs?
What is Uribel Tabs used for?
Symptoms of irritative urination such as frequency, urgency, painful urination, and loss of bladder control
Urinary symptoms related to urinary tract infections (UTIs)
Urinary symptoms caused by medical procedures
How Uribel Tabs works
Uribel Tabs is a combination medication made of 5 different medicines, which all work differently.
Hyoscyamine sulfate relaxes the bladder muscle to limit bladder spasms and the urge to urinate.
Methenamine is broken down to formaldehyde in acidic urine, which kills bacteria and stops its growth.
Methylene blue works as an antiseptic, meaning it prevents growth of bacteria.
Phenyl salicylate works as a pain reliever.
Benzoic acid keeps your urine acidic to help methenamine break down into formaldehyde.
Drug Facts
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What are the side effects of Uribel Tabs?
Common Side Effects
- Rapid heartbeat
- Blurred vision
- Dizziness
- Drowsiness
- Blue to blue-green urine or stool
- Redness of your skin (flushing)
- Difficult urination
- Can't empty your bladder fully
- Dry mouth
- Nausea
- Vomiting
Serious Side Effects
- Serious allergic reactions: itching, rash, severe dizziness, swelling, trouble breathing
Source: DailyMed
The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Blurry vision
- Change in the amount of urine
- Fast or irregular heartbeat
- Trouble passing urine
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Pros and cons of Uribel Tabs
Pros
Combination of 5 medications that all work in different ways to relieve your urinary symptoms
Taken by mouth
Option for children ages 6 years and older
Cons
Needs to be taken 4 times per day
Not available as a generic
Risk of serotonin syndrome if taken with medications that raise serotonin levels
Pharmacist tips for Uribel Tabs
You can take Uribel Tabs with or without food. Drink plenty of water after taking each dose to make sure your kidneys have good blood flow.
Uribel Tabs works best when your urine is acidic. Limit foods that make your urine less acidic (alkaline-producing foods) such as fruits, vegetables, nuts, and legumes. Avoid any medications that lower the acidity in your body such as antacids or sodium bicarbonate.
If you experience a rapid pulse, dizziness, or blurred vision, stop taking Uribel Tabs right away and contact your healthcare professional (HCP). Don't drive or do things that require you to focus until you know how this medication makes you feel.
Uribel Tabs might turn your urine or stool blue or blue-green because of the methylene blue component of the medication. This isn't harmful and should go away after you stop taking the medication.
Uribel Tabs can slow down gut movement and affect how your body absorbs certain medications. Let your care team know that you're taking Uribel Tabs because they might need to make adjustments to medications that you're already taking or monitor you more closely for side effects.
You can have an allergic reaction to Uribel Tabs if you've had a reaction to belladonna alkaloids, such as atropine and scopolamine (Transderm Scop), or salicylates, such as aspirin. Let your HCP know if you've had allergies to these medications in the past.
It isn't known if Uribel Tabs can harm you and your unborn baby, so it should only be used if it's really needed. The hyoscyamine and methenamine components of the medication cross the placenta, but it isn't known what effect this has on your unborn baby. Let your prescriber know if you're pregnant before taking Uribel Tabs.
Store Uribel Tabs at room temperature in a container that will protect it from light.
Frequently asked questions about Uribel Tabs
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What are the risks and warnings for Uribel Tabs?
Uribel Tabs can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Agitation, drowsiness, or confusion
Risk factors: Age 65 years and older
Uribel Tabs can cause excitement, agitation, drowsiness, or confusion, especially in older adults. Let your prescriber know if this becomes bothersome.
Risk of serious medication interaction
Risk factors: Taking with certain psychiatric medications
If you take any medication that raises the level of serotonin in your body, such as fluoxetine (Prozac), let your HCP know before starting Uribel Tabs. Uribel Tabs contains methylene blue, which prevents the breakdown of serotonin. If you take it with medications that raises serotonin levels, you might be at risk for a serious side effect called serotonin syndrome. Symptoms of serotonin syndrome include confusion, muscle twitching, shaking, and diarrhea.
Allergic reactions
Risk factors: Allergic reaction to belladonna alkaloids or salicylates
You can have an allergic reaction to Uribel Tabs if you've had a reaction to belladonna alkaloids, such as atropine and scopolamine (Transderm Scop), or salicylates, such as aspirin. Let your prescriber know if you've had allergies to these medications in the past.
Stomach-related problems
Risk factors: Stomach ulcer
Uribel Tabs can slow down your digestion. This can cause problems if you have a stomach ulcer. Let your prescriber know if you're being treated for a stomach ulcer before you start taking Uribel Tabs.
Long-term use
It isn't known if it's safe to take Uribel Tabs for a prolonged period of time. It’s important for you and your prescriber to weigh the risk and benefits of taking this medication long-term.
Uribel Tabs dosage forms
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 81.6mg/0.12mg | 30 tablets | $59.06 | $1.97 |
Typical dosing for Uribel Tabs
Each Uribel Tabs tablet contains:
81.6 mg of methenamine
9 mg of benzoic acid
36.2 mg of phenyl salicylate
10.8 mg of methylene blue
0.12 mg of hyoscyamine sulfate.
Adults:
The typical dose is 1 capsule by mouth 4 times per day with plenty of fluids.
Children (older than 6 years of age):
Your child's pediatrician will determine the dose based on your child's individual needs.
Note: There are medications similar to Uribel Tabs, but they can differ slightly in dosages of individual ingredients, such as Urimar-T. Ask a healthcare professional if you have questions about similar medications.
What are alternatives to Uribel Tabs?
Symptoms of irritative urination such as frequency, urgency, painful urination, and loss of bladder control
Urinary symptoms related to urinary tract infections (UTIs)
Urinary symptoms caused by medical procedures
Relief of urinary pain, burning, urgency, and frequency caused by infection, trauma, catheter use, or surgery
Uribel Tabs images
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References
Best studies we foundAllegis Pharmaceuticals, LLC. (2023). Urimar-T Caps- methenamine, sodium phosphate, monobasic, monohydrate, phenyl salicylate, methylene blue, and hyoscyamine sulfate capsule [package insert]. DailyMed.
MedlinePlus. (2017). Methenamine.
Method Pharmaceuticals, LLC. (2023). Uro-MP- methenamine, sodium phosphate, monobasic, anhydrous, phenyl salicylate, methylene blue and hyoscyamine sulfate capsule [package insert]. DailyMed.
Mission Pharmacal Company. (2023). Uribel- methenamine, sodium phosphate, monobasic, monohydrate, phenyl salicylate, methylene blue, and hyoscyamine sulfate capsule [package insert]. DailyMed.
Mission Pharmacal Company. (2024). Uribel tabs- methenamine, benzoic acid, phenyl salicylate, methylene blue, and hyoscyamine sulfate tablet, coated [package insert]. DailyMed.
Star Pharmaceuticals, LLC. (2017). Hyophen- methenamine, benzoic acid, phenyl salicylate, methylene blue, and hyoscyamine sulfate tablet [package insert]. DailyMed.
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