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Urelle

hyoscyamine / methenamine / phenyl salicylate / sodium phosphate monobasic / methylene blue
Used for Urinary Tract Infection
Used for Urinary Tract Infection

Urelle is a combination of 5 different medications used to treat pain and irritation of the urinary tract caused by lower urinary tract infections or medical procedures. It works as an antiseptic that stops the growth of bacteria in the urine, an analgesic that eases pain, and an urinary antispasmodic that lessens the urge to urinate often. Urelle is taken by mouth, typically 4 times a day with plenty of water. It can be used by adults and children ages 6 years and older. Urelle doesn't cause many side effects, but it can sometimes cause your urine and stools to turn blue to blue-green in color; this effect is harmless and temporary.

Last reviewed on March 26, 2024
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What is Urelle?

What is Urelle used for?

  • Symptoms of irritative urination such as frequency, urgency, painful urination, and loss of bladder control

  • Urinary symptoms related to urinary tract infections (UTIs)

  • Urinary symptoms caused by medical procedures

How Urelle works

Urelle is a combination medication made of 5 different medicines, which all work differently:

  • Hyoscyamine sulfate relaxes the bladder muscle to limit bladder spasms and the urge to urinate.

  • Methenamine is broken down to formaldehyde in acidic urine, which kills bacteria and stops its growth.

  • Methylene blue works as an antiseptic, meaning it prevents growth of bacteria.

  • Phenyl salicylate works as a pain reliever.

  • Sodium phosphate monobasic keeps your urine acidic to help methenamine break down into formaldehyde.

Are you looking for information on Uribel Tabs instead?

Drug Facts

Common BrandsUrelle
Drug ClassUrinary antispasmodic / Antiseptic
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
$336.95(save 74.73%)
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$85.14
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What are the side effects of Urelle?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dry mouth
  • Nausea
  • Vomiting
  • Blue urine or discolored stool

Other Side Effects

  • Blurred vision
  • Dizziness
  • Drowsiness
  • Redness of your skin (flushing)
  • Rapid heartbeat
  • Difficult urination
  • Cannot empty your bladder fully

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reactions: itching, rash, severe dizziness, swelling, or trouble breathing

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Blurry vision
  • Change in the amount of urine
  • Fast or irregular heartbeat
  • Trouble passing urine

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Blue or blue-green urine or stools
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Flushing
  • Nausea
  • Vomiting
pros-and-cons

Pros and cons of Urelle

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Pros

Combination of 5 medicines that all work in different ways to relieve your urinary symptoms

Taken by mouth

Option for children ages 6 years and older

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Cons

Needs to be taken 4 times per day

Not available as generic

Risk of serotonin syndrome if taken with medications that raise serotonin levels

pharmacist-tips

Pharmacist tips for Urelle

pharmacist
  • If you experience a rapid pulse, dizziness, or blurred vision, stop taking Urelle right away and contact your healthcare professional (HCP). Don't drive or do things that require you to focus until you know how this medication makes you feel.

    • Urelle might turn your urine blue because of the methylene blue component of the medication. This isn't harmful and should go away after you stop taking the medication.

      • You can have an allergic reaction to Urelle if you've had a reaction to belladonna alkaloids, such as atropine and scopolamine (Transderm Scop), or salicylates, such as aspirin. Let your HCP know if you've had allergies to these medications in the past.

        • You can take Urelle with or without food. Drink plenty of water after taking each dose to make sure your kidneys have good blood flow.

          • Urelle works best when your urine is acidic. Limit foods that make your urine less acidic (alkaline-producing foods) such as fruits, vegetables, nuts, and legumes. Avoid any medications that lower the acidity in your body such as antacids or sodium bicarbonate.

            • Store this medication at room temperature in a container that will protect it from light.

              faqs

              Frequently asked questions about Urelle

              Where to buy Urelle?
              Urelle is only available with a prescription from your healthcare professional (HCP). If your HCP thinks you'll benefit from this medication, they'll send the prescription to your local pharmacy. Make sure to call ahead to the pharmacy to check whether they have Urelle in stock. Urelle isn't available for purchase over-the-counter.
              Can Urelle clear a bladder infection?
              Urelle isn't likely to clear a bladder infection. This medication contains certain ingredients, such as methenamine, that can kill or prevent the growth of bacteria. But they might not be enough to fight off the infection. If you currently have a bladder infection, your HCP will likely prescribe you an antibiotic to treat the UTI.
              How long does it take Urelle to work?
              More research is needed to better understand the timing of when each individual component of Urelle might kick in. But based on available information of similar medications, Urelle is likely to get absorbed fairly. In order for Urelle to work best, you should take it with plenty of fluids. If you're not experiencing symptom relief after taking Urelle, speak with your care team.
              Are Urelle and Uribel Tab the same?
              Urelle and Uribel Tabs are very similar, but they're not the same. Both medications can treat the same urinary tract symptoms. One main difference between them is that they differ in one active ingredient: Uribel Tabs contains benzoic acid as the medication that lowers urine pH, but Urelle contains sodium phosphate monobasic instead.
              Does Urelle cause weight gain?
              Weight gain isn't a commonly reported side effect of Urelle. If you notice a major change in your weight after starting Urelle, you should speak with your healthcare professional (HCP). They can try to help you figure out the cause and let you know if you need more medical attention.
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              What are the risks and warnings for Urelle?

              Urelle can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Risk of serious medication interaction

              • Risk factors: Taking medications that raise serotonin levels at the same time

                If you take any medication that raises the level of serotonin in your body, such as fluoxetine (Prozac), let your HCP know before starting Urelle. Urelle contains methylene blue, which prevents the break down of serotonin. If you take it with medications that raise serotonin levels, you might be at risk for a serious side effect called serotonin syndrome. Symptoms of serotonin syndrome include confusion, muscle twitching, shaking, and diarrhea.

                risk-warning

                Allergic reactions

                • Risk factors: Allergic reaction to belladonna alkaloids or salicylates

                  You can have an allergic reaction to Urelle if you've had a reaction to belladonna alkaloids, such as atropine and scopolamine (Transderm Scop), or salicylates, such as aspirin. Let your provider know if you've had allergies to these medications in the past.

                  dosage

                  Urelle dosage forms

                  The average cost for 30 tablets of 81mg/0.12mg of Urelle is $85.14 with a free GoodRx coupon. This is 74.73% off the average retail price of $336.95.
                  tablet
                  Tablet
                  DosageQuantityPrice as low asPrice per unit
                  81mg/0.12mg30 tablets$85.14$2.84

                  Typical dosing for Urelle

                  Each Urelle capsule contains:

                  • 81 mg of methenamine

                  • 40.8 mg of sodium phosphate monobasic

                  • 32.4 mg of phenyl salicylate

                  • 10.8 mg of methylene blue

                  • 0.12 mg of hyoscyamine sulfate

                  Adults:

                  • The typical dose is 1 capsule by mouth 4 times per day with plenty of fluids.

                  Children (older than 6 years of age):

                  • The dose will depend on the child's individual needs. Talk with their pediatrician.

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                  alternatives

                  What are alternatives to Urelle?

                  There are a number of medications that your doctor can prescribe in place of Urelle. Compare a few possible alternatives below.
                  Urelle
                  Used for:
                  • Symptoms of irritative urination such as frequency, urgency, painful urination, and loss of bladder control

                  • Urinary symptoms related to urinary tract infections (UTIs)

                  • Urinary symptoms caused by medical procedures

                  $85.14 Lowest GoodRx priceView Prices
                  Used for:
                  • Relief of urinary pain, burning, urgency, and frequency caused by infection, trauma, catheter use, or surgery

                  $4.71 Lowest GoodRx priceView Prices
                  Used for:
                  • Symptoms of irritative urination such as frequency, urgency, painful urination, and loss of bladder control

                  • Urinary symptoms related to urinary tract infections (UTIs)

                  • Urinary symptoms caused by medical procedures

                  $59.55 Lowest GoodRx priceView Prices

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                  References

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