Urelle
Urelle is a combination of 5 different medications used to treat pain and irritation of the urinary tract caused by lower urinary tract infections or medical procedures. It works as an antiseptic that stops the growth of bacteria in the urine, an analgesic that eases pain, and an urinary antispasmodic that lessens the urge to urinate often. Urelle is taken by mouth, typically 4 times a day with plenty of water. It can be used by adults and children ages 6 years and older. Urelle doesn't cause many side effects, but it can sometimes cause your urine and stools to turn blue to blue-green in color; this effect is harmless and temporary.
What is Urelle?
What is Urelle used for?
Symptoms of irritative urination such as frequency, urgency, painful urination, and loss of bladder control
Urinary symptoms related to urinary tract infections (UTIs)
Urinary symptoms caused by medical procedures
How Urelle works
Urelle is a combination medication made of 5 different medicines, which all work differently:
Hyoscyamine sulfate relaxes the bladder muscle to limit bladder spasms and the urge to urinate.
Methenamine is broken down to formaldehyde in acidic urine, which kills bacteria and stops its growth.
Methylene blue works as an antiseptic, meaning it prevents growth of bacteria.
Phenyl salicylate works as a pain reliever.
Sodium phosphate monobasic keeps your urine acidic to help methenamine break down into formaldehyde.
Drug Facts
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What are the side effects of Urelle?
Common Side Effects
- Dry mouth
- Nausea
- Vomiting
- Blue urine or discolored stool
Other Side Effects
- Blurred vision
- Dizziness
- Drowsiness
- Redness of your skin (flushing)
- Rapid heartbeat
- Difficult urination
- Cannot empty your bladder fully
Serious Side Effects
- Serious allergic reactions: itching, rash, severe dizziness, swelling, or trouble breathing
Source: DailyMed
The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Blurry vision
- Change in the amount of urine
- Fast or irregular heartbeat
- Trouble passing urine
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Pros and cons of Urelle
Pros
Combination of 5 medicines that all work in different ways to relieve your urinary symptoms
Taken by mouth
Option for children ages 6 years and older
Cons
Needs to be taken 4 times per day
Not available as generic
Risk of serotonin syndrome if taken with medications that raise serotonin levels
Pharmacist tips for Urelle
If you experience a rapid pulse, dizziness, or blurred vision, stop taking Urelle right away and contact your healthcare professional (HCP). Don't drive or do things that require you to focus until you know how this medication makes you feel.
Urelle might turn your urine blue because of the methylene blue component of the medication. This isn't harmful and should go away after you stop taking the medication.
You can have an allergic reaction to Urelle if you've had a reaction to belladonna alkaloids, such as atropine and scopolamine (Transderm Scop), or salicylates, such as aspirin. Let your HCP know if you've had allergies to these medications in the past.
You can take Urelle with or without food. Drink plenty of water after taking each dose to make sure your kidneys have good blood flow.
Urelle works best when your urine is acidic. Limit foods that make your urine less acidic (alkaline-producing foods) such as fruits, vegetables, nuts, and legumes. Avoid any medications that lower the acidity in your body such as antacids or sodium bicarbonate.
Store this medication at room temperature in a container that will protect it from light.
Frequently asked questions about Urelle
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What are the risks and warnings for Urelle?
Urelle can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk of serious medication interaction
Risk factors: Taking medications that raise serotonin levels at the same time
If you take any medication that raises the level of serotonin in your body, such as fluoxetine (Prozac), let your HCP know before starting Urelle. Urelle contains methylene blue, which prevents the break down of serotonin. If you take it with medications that raise serotonin levels, you might be at risk for a serious side effect called serotonin syndrome. Symptoms of serotonin syndrome include confusion, muscle twitching, shaking, and diarrhea.
Allergic reactions
Risk factors: Allergic reaction to belladonna alkaloids or salicylates
You can have an allergic reaction to Urelle if you've had a reaction to belladonna alkaloids, such as atropine and scopolamine (Transderm Scop), or salicylates, such as aspirin. Let your provider know if you've had allergies to these medications in the past.
Urelle dosage forms
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 81mg/0.12mg | 30 tablets | $85.14 | $2.84 |
Typical dosing for Urelle
Each Urelle capsule contains:
81 mg of methenamine
40.8 mg of sodium phosphate monobasic
32.4 mg of phenyl salicylate
10.8 mg of methylene blue
0.12 mg of hyoscyamine sulfate
Adults:
The typical dose is 1 capsule by mouth 4 times per day with plenty of fluids.
Children (older than 6 years of age):
The dose will depend on the child's individual needs. Talk with their pediatrician.
How much does Urelle cost?
What are alternatives to Urelle?
Symptoms of irritative urination such as frequency, urgency, painful urination, and loss of bladder control
Urinary symptoms related to urinary tract infections (UTIs)
Urinary symptoms caused by medical procedures
Relief of urinary pain, burning, urgency, and frequency caused by infection, trauma, catheter use, or surgery
Symptoms of irritative urination such as frequency, urgency, painful urination, and loss of bladder control
Urinary symptoms related to urinary tract infections (UTIs)
Urinary symptoms caused by medical procedures
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References
Best studies we foundMcDonnell, G., et al. (1999). Antiseptics and disinfectants: Activity, action, and resistance. Clinical Microbiology Reviews.
Meda Pharmaceuticals. (2015). Urelle- hyoscyamine sulfate, methenamine, methylene blue, phenyl salicylate, and sodium phosphate, monobasic, monohydrate tablet [package insert]. DailyMed.
Mission Pharmacal Company. (2024). Uribel Tabs- methenamine, benzoic acid, phenyl salicylate, methylene blue, and hyoscyamine sulfate tablet, coated [package insert]. DailyMed.
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