Compare Urogesic Blue vs. Pyridium

Urogesic Blue (methenamine / sodium phosphate / methylene blue / hyoscyamine) and Pyridium (phenazopyridine) are both medications used to relieve urinary discomfort, but they have some important differences. Urogesic Blue is a combination of urinary antispasmodic and antiseptic agents, while Pyridium is an analgesic. Both medications can help with symptoms like pain and discomfort from urinary tract infections (UTIs), but Urogesic Blue is also used for bladder spasms and discomfort during medical procedures. Urogesic Blue is taken by prescription only, typically four times a day, and can turn your urine blue. Pyridium is available both over-the-counter and by prescription, is usually taken three times a day, and can turn your urine orange. Urogesic Blue has a generic alternative, while Pyridium is available as a lower-cost generic. Common side effects of Urogesic Blue include dry mouth and nausea, while Pyridium can cause headache and upset stomach. Urogesic Blue may interact with antacids and certain antibiotics, whereas Pyridium has fewer drug interactions but should not be used for more than two days without consulting a healthcare provider.