Urelle
Urelle is a combination of 5 different medications used to treat pain and irritation of the urinary tract caused by lower urinary tract infections or medical procedures. It works as an antiseptic that stops the growth of bacteria in the urine, an analgesic that eases pain, and an urinary antispasmodic that lessens the urge to urinate often. Urelle is taken by mouth, typically 4 times a day with plenty of water. It can be used by adults and children ages 6 years and older. Urelle doesn't cause many side effects, but it can sometimes cause your urine and stools to turn blue to blue-green in color; this effect is harmless and temporary.
What is Urelle?
What is Urelle used for?
- Symptoms of irritative urination such as frequency, urgency, painful urination, and loss of bladder control
- Urinary symptoms related to urinary tract infections (UTIs)
- Urinary symptoms caused by medical procedures
How Urelle works
Urelle is a combination medication made of 5 different medicines, which all work differently:
- Hyoscyamine sulfate relaxes the bladder muscle to limit bladder spasms and the urge to urinate.
- Methenamine is broken down to formaldehyde in acidic urine, which kills bacteria and stops its growth.
- Methylene blue works as an antiseptic, meaning it prevents growth of bacteria.
- Phenyl salicylate works as a pain reliever.
- Sodium phosphate monobasic keeps your urine acidic to help methenamine break down into formaldehyde.
Drug facts
| Common Brands | Urelle |
|---|---|
| Drug Class | Urinary antispasmodic / Antiseptic |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Side effects of Urelle
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Dry mouth
- Nausea
- Vomiting
- Blue urine or discolored stool
Less Common Side Effects
- Blurred vision
- Dizziness
- Drowsiness
- Redness of your skin (flushing)
- Rapid heartbeat
- Difficult urination
- Cannot empty your bladder fully
Urelle serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reactions: itching, rash, severe dizziness, swelling, or trouble breathing
The following Urelle side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Blurry vision
- Change in the amount of urine
- Fast or irregular heartbeat
- Trouble passing urine
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
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Pros and cons of Urelle
Pros
- Combination of 5 medicines that all work in different ways to relieve your urinary symptoms
- Taken by mouth
- Option for children ages 6 years and older
Cons
- Needs to be taken 4 times per day
- Not available as generic
- Risk of serotonin syndrome if taken with medications that raise serotonin levels
Pharmacist tips for Urelle
- If you experience a rapid pulse, dizziness, or blurred vision, stop taking Urelle right away and contact your healthcare professional (HCP). Don't drive or do things that require you to focus until you know how this medication makes you feel.
- Urelle might turn your urine blue because of the methylene blue component of the medication. This isn't harmful and should go away after you stop taking the medication.
- You can have an allergic reaction to Urelle if you've had a reaction to belladonna alkaloids, such as atropine and scopolamine (Transderm Scop), or salicylates, such as aspirin. Let your HCP know if you've had allergies to these medications in the past.
- You can take Urelle with or without food. Drink plenty of water after taking each dose to make sure your kidneys have good blood flow.
- Urelle works best when your urine is acidic. Limit foods that make your urine less acidic (alkaline-producing foods) such as fruits, vegetables, nuts, and legumes. Avoid any medications that lower the acidity in your body such as antacids or sodium bicarbonate.
- Store this medication at room temperature in a container that will protect it from light.
Risks and warnings for Urelle
Urelle can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk of serious medication interaction
- Risk factors: Taking medications that raise serotonin levels at the same time
If you take any medication that raises the level of serotonin in your body, such as fluoxetine (Prozac), let your HCP know before starting Urelle. Urelle contains methylene blue, which prevents the break down of serotonin. If you take it with medications that raise serotonin levels, you might be at risk for a serious side effect called serotonin syndrome. Symptoms of serotonin syndrome include confusion, muscle twitching, shaking, and diarrhea.
Allergic reactions
- Risk factors: Allergic reaction to belladonna alkaloids or salicylates
You can have an allergic reaction to Urelle if you've had a reaction to belladonna alkaloids, such as atropine and scopolamine (Transderm Scop), or salicylates, such as aspirin. Let your provider know if you've had allergies to these medications in the past.
Urelle dosage
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 81mg/0.12mg | 30 tablets | $289.20 | $9.64 |
Typical dosage for Urelle
Each Urelle capsule contains:
- 81 mg of methenamine
- 40.8 mg of sodium phosphate monobasic
- 32.4 mg of phenyl salicylate
- 10.8 mg of methylene blue
- 0.12 mg of hyoscyamine sulfate
Adults:
- The typical dose is 1 capsule by mouth 4 times per day with plenty of fluids.
Children (older than 6 years of age):
- The dose will depend on the child's individual needs. Talk with their pediatrician.
How much does Urelle cost?
$289.20
