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Trelstar

Trelstar Side Effects

Julia Lee, PharmD, BCOPDaisy Chau, PharmD
Reviewed by Julia Lee, PharmD, BCOP, Daisy Chau, PharmD
Last reviewed on September 22, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

3.75 mg:

  • Hot flashes (59%)
  • Bone pain (12%)
  • Erectile dysfunction (7%)

11.25 mg:

  • Hot flashes (73%)
  • Bone pain (13%)
  • Headache (7%)

22.5 mg:

  • Hot flashes (73%)
  • Flu infection (16%)
  • High blood pressure (14%)
  • Urinary tract infection (12%)
  • Back pain (11%)
  • Erectile dysfunction (10%)

Less Common Side Effects

3.75 mg:

  • Headache
  • Tiredness
  • Dizziness
  • Diarrhea
  • Trouble sleeping

11.25 mg:

  • Pain at the injection site
  • Dizziness
  • Nausea
  • Swelling in the legs
  • Erectile dysfunction
  • Painful urination

22.5 mg:

  • Swelling in the arms and legs
  • Bronchitis
  • Rise in blood sugar
  • Joint pain
  • Headache
  • Trouble sleeping
  • Trouble urinating

Trelstar serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious allergic reaction: rash, swelling of the face or throat, trouble breathing
  • Heart attack: chest pain, shortness of breath, rapid breathing, sweating, fatigue, dizziness, nausea, vomiting
  • Heart rhythm problems: fast or uneven heartbeat, fainting, dizziness
  • Stroke: sudden numbness or weakness, confusion, trouble talking, trouble seeing, dizziness, trouble walking
  • Seizure: sudden jerking or shaking, loss of consciousness, confusion, trouble speaking

Source: DailyMed

The following Trelstar side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

For children

Diarrhea

loss of appetite

nausea

stomach pain

weakness

Less common

For children

Anxiety

body aches or pain

chills

cough

cough producing mucus

difficulty with breathing

ear congestion

fever

general feeling of discomfort or illness

headache

joint pain

loss of voice

mood or mental changes, including abnormal crying, aggression, agitation, delusions, irritability, nervousness, or restlessness

muscle aches and pains

nasal congestion

runny nose

shivering

sneezing

sore throat

sweating

tightness in the chest

trouble sleeping

unusual tiredness or weakness

vomiting

For adult men

Bladder pain

bloating or swelling of the face, arms, hands, lower legs, or feet

bloody or cloudy urine

blurred vision

chest pain

cough producing mucus

decrease in urine volume or frequency of urination

difficult or labored breathing

difficult, burning, or painful urination

difficulty in passing urine

dizziness

dry mouth

flushed, dry skin

frequent urge to urinate

fruit-like breath odor

headache

increased hunger

increased thirst

increased urination

loss of consciousness

lower back or side pain

nausea

nervousness

pale skin

pounding in the ears

rapid weight gain

slow or fast heartbeat

stomach ache

sweating

tightness in the chest

tingling of the hands or feet

troubled breathing

troubled breathing with exertion

unexplained weight loss

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight gain or loss

vomiting

Incidence not known

For children

Blurred or loss of vision

depression

difficulty with swallowing

disturbed color perception

dizziness

double vision

halos around lights

hives, itching, skin rash

nervousness

night blindness

overbright appearance of lights

pounding in the ears

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

seizures

slow or fast heartbeat

thoughts of killing oneself

For adult men

Anxiety

changes in skin color

changes in vision

chest discomfort

cold, clammy, or pale skin

confusion

dizziness or lightheadedness

fainting

inability to speak

irregular heartbeat

numbness or tingling in the face, arms, or legs

pain

pain or discomfort in the arms, jaw, back, or neck

pain, redness, or swelling in the arm or leg

seizures

severe or sudden headache

slow heart rate

slurred speech

sudden shortness of breath or troubled breathing

temporary blindness

tenderness

trouble speaking, thinking, or walking

weakness in the arm or leg on one side of the body, sudden and severe

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For children

Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

stuffy or runny nose

For adult men

Bone pain

chills

decrease in testicle size

decreased interest in sexual intercourse

diarrhea

feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest

fever

general feeling of discomfort or illness

inability to have or keep an erection

joint pain

leg pain

loss in sexual ability, desire, drive, or performance

loss of appetite

muscle aches and pains

redness of the face, neck, arms, and occasionally, upper chest

runny nose

shivering

sore throat

sudden sweating

trouble sleeping

Less common

For children

Change in hearing

dryness or soreness of the throat

ear drainage

earache

hoarseness

itching of the ears

pain or tenderness around the eyes and cheekbones

tender, swollen glands in the neck

voice changes

For adult men

Back pain

belching

body aches or pain

breast pain

burning, dry, or itching eyes

congestion

crying

depersonalization

difficulty having a bowel movement

difficulty with moving

discharge or excessive tearing

dysphoria

euphoria

eye pain

heartburn

hoarseness

indigestion

injection site pain

itching or rash

lack or loss of strength

leg cramps

loss of appetite

muscle aching or cramping

muscle pains or stiffness

paranoia

quick to react or overreact emotionally

rapidly changing moods

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

runny nose

stomach discomfort, upset, or pain

swelling of the breasts or breast soreness in both females and males

swollen joints

tender, swollen glands in the neck

trouble swallowing

voice changes

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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