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Zoladex

Zoladex Side Effects

Allison Gourley, PharmD
Reviewed by Carter Havican, PharmD, Allison Gourley, PharmD
Last reviewed on August 17, 2021

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Hot flashes (46%)
  • Diarrhea (40%)
  • Nausea (9%)
  • Skin rash (8%)

Less Common Side Effects

  • Sexual dysfunction
  • Body pain
  • Breast pain
  • Headache
  • Dizziness
  • Edema (swelling)
  • Difficulty urinating
  • Urinary tract infection

Zoladex serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reactions
  • Heart attack: Chest pain, pain radiating or spreading to your arm or shoulder, cold, sweat, trouble breathing
  • Stroke: Confusion, facial drooping, weakness on one side of the body, trouble walking or speaking, sudden, severe headache
  • QT prolongation syndrome: Palpitations, fluttering in your chest
  • Shock: Racing heart, fever, cold and pale skin, nausea and vomiting, trouble breathing, feeling faint

Source: DailyMed

The following Zoladex side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

For all adults

Less common

Fast or irregular heartbeat

Rare

Bone, muscle, or joint pain

changes in skin color of the face

fainting

fast or irregular breathing

numbness or tingling of the hands or feet

puffiness or swelling of the eyelids or around the eyes

skin rash, hives, or itching

sudden, severe decrease in blood pressure and collapse

tightness in the chest

troubled breathing

For females only

Rare

Anxiety

deepening of voice

increased hair growth

mental depression

mood changes

For males only

Rare

Pain in the chest

pain in the groin or legs (especially in the calves of the legs)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For all adults

More common

Sudden sweating and feelings of warmth (also called hot flashes)

Less common

Blurred vision

burning, itching, redness, or swelling at the place of injection

decreased interest in sexual intercourse

dizziness

headache

nausea or vomiting

swelling and increased tenderness of the breasts

swelling of the feet or lower legs

trouble sleeping

weight gain

For females only

More common

Light, irregular vaginal bleeding

stopping of menstrual periods

Less common

Burning, dryness, or itching of the vagina

pelvic pain

For males only

Less common

Bone pain

constipation

decreased size of the testicles

inability to have or keep an erection

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.

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