Lupron Depot Ped

Lupron Depot-Ped Side Effects

Reviewed by Dalga Surofchy, PharmD, APh, Allison Gourley, PharmD

Last reviewed on July 26, 2021

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Injection site reactions, such as pain and swelling (9%)
Mood changes (5%)
Pain throughout body (3%)
Headache (3%)
Acne (3%)
Serious skin rash (erythema multiforme, 3%)
Swelling of vagina (vaginitis), vaginal bleeding, and vaginal discharge/fluids (3%)

^{*Side effects for injections into the muscle}

Lupron Depot-Ped serious side effects

Contact your healthcare provider immediately if you experience any of the following.

Allergic reactions

Source: FDA

The following Lupron Depot-Ped side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

For adults

Less common

Fast or irregular heartbeat

Rare

Bone, muscle, or joint pain

fainting

fast or irregular breathing

numbness or tingling of the hands or feet

puffiness or swelling of the eyelids or around the eyes

skin rash, hives, or itching

sudden, severe decrease in blood pressure and collapse

tightness in the chest

trouble breathing

For males only (adults)

More common

Arm, back, or jaw pain

bloody or cloudy urine

blurred vision

chest pain or discomfort

difficult, burning, or painful urination

difficulty with moving

dizziness

frequent urge to urinate

headache

increased urge to urinate during the night

muscle pain or stiffness

nausea

nervousness

pain in the joints

pale skin

pounding in the ears

slow or fast heartbeat

sweating

unusual bleeding or bruising

unusual tiredness or weakness

waking to urinate at night

Rare

Pain in the groin or legs (especially in the calves)

Incidence not known

Altered mental status

cold, clammy, pale skin

confusion

double vision

irregular heartbeat

visual changes

vomiting

For females only (adults)

Rare

Anxiety

deepening of voice

increased hair growth

mental depression

mood changes

For children

More common

Body aches or pain

chills

cough

cough producing mucus

difficulty in breathing

ear congestion

fever

headache

loss of voice

muscle aches

noisy breathing

pain or redness at the injection site

runny or stuffy nose

sneezing

sore throat

tightness in the chest

unusual tiredness or weakness

Less common

Irritability

mood or mental changes

Rare

Burning, itching, or swelling at the injection site

Incidence not known

Seizures

For females only (children)—expected in first few weeks

Rare

Vaginal bleeding (continuing)

white vaginal discharge (continuing)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For adults

More common

Sudden sweating and feeling of warmth (hot flashes)

Less common

Bleeding, bruising, burning, itching, pain, redness, or swelling at the injection site

decreased interest in sexual intercourse

swelling of the feet or lower legs

swelling or increased tenderness of the breasts

trouble sleeping

weight gain

For females only (adults)

More common