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Lupron Depot-Ped Coupon - Lupron Depot-Ped 1 pre-filled syringe of 30mg kit

Lupron Depot-Ped

leuprolide
Used for Central Precocious Puberty
Used for Central Precocious Puberty

Lupron Depot-Ped (leuprolide) is an injectable medication that works well to prevent early puberty in children 2 years of age and older. It must be given by a healthcare provider, and it's either injected under the skin or into the muscle.

Reviewed by:
reviewer
Dalga Surofchy, PharmD, APh
reviewer
Allison Gourley, PharmD
Last reviewed on July 26, 2021
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsAlternativesLatest newsImagesPricesMedicare
basics-icon

What is Lupron Depot-Ped (leuprolide)?

What is Lupron Depot-Ped (leuprolide) used for?

  • Precocious puberty (puberty that starts at an early age)

How Lupron Depot-Ped (leuprolide) works

Lupron Depot-Ped (leuprolide) is a gonadotropin-releasing hormone (GnRH) agonist, which is a synthetic (man-made) hormone similar to the GnRH your body naturally makes. It lowers reproductive hormone levels, estrogen and testosterone, which are a part of the process of puberty.

Are you looking for information on Eligard or Lupron Depot (leuprolide) for advanced prostate cancer instead?

Drug Facts

Common BrandsLupron Depot-Ped, Fensolvi
Drug ClassGnRH agonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Lupron Depot-Ped (leuprolide)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Injection site reactions, such as pain and swelling (9%)
  • Mood changes (5%)
  • Pain throughout body (3%)
  • Headache (3%)
  • Acne (3%)
  • Serious skin rash (erythema multiforme, 3%)
  • Swelling of vagina (vaginitis), vaginal bleeding, and vaginal discharge/fluids (3%)
^*Side effects for injections into the muscle^

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Allergic reactions

Source: FDA

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

For adults

Less common

Fast or irregular heartbeat

Rare

Bone, muscle, or joint pain

fainting

fast or irregular breathing

numbness or tingling of the hands or feet

puffiness or swelling of the eyelids or around the eyes

skin rash, hives, or itching

sudden, severe decrease in blood pressure and collapse

tightness in the chest

trouble breathing

For males only (adults)

More common

Arm, back, or jaw pain

bloody or cloudy urine

blurred vision

chest pain or discomfort

difficult, burning, or painful urination

difficulty with moving

dizziness

frequent urge to urinate

headache

increased urge to urinate during the night

muscle pain or stiffness

nausea

nervousness

pain in the joints

pale skin

pounding in the ears

slow or fast heartbeat

sweating

unusual bleeding or bruising

unusual tiredness or weakness

waking to urinate at night

Rare

Pain in the groin or legs (especially in the calves)

Incidence not known

Altered mental status

cold, clammy, pale skin

confusion

double vision

irregular heartbeat

visual changes

vomiting

For females only (adults)

Rare

Anxiety

deepening of voice

increased hair growth

mental depression

mood changes

For children

More common

Body aches or pain

chills

cough

cough producing mucus

difficulty in breathing

ear congestion

fever

headache

loss of voice

muscle aches

noisy breathing

pain or redness at the injection site

runny or stuffy nose

sneezing

sore throat

tightness in the chest

unusual tiredness or weakness

Less common

Irritability

mood or mental changes

Rare

Burning, itching, or swelling at the injection site

Incidence not known

Seizures

For females only (children)—expected in first few weeks

Rare

Vaginal bleeding (continuing)

white vaginal discharge (continuing)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For adults

More common

Sudden sweating and feeling of warmth (hot flashes)

Less common

Bleeding, bruising, burning, itching, pain, redness, or swelling at the injection site

decreased interest in sexual intercourse

swelling of the feet or lower legs

swelling or increased tenderness of the breasts

trouble sleeping

weight gain

For females only (adults)

More common

Light, irregular vaginal bleeding

stopping of menstrual periods

Less common

Burning, dryness, or itching of the vagina

pelvic pain

For males only (adults)

More common

Back pain

chills

constipation

cough

diarrhea

fever

general feeling of discomfort or illness

loss of appetite

pain or discomfort at the injection site

redness of the face, neck, arms, and occasionally, upper chest

runny nose

shivering

sore throat

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Less common

Decreased size of the testicles

inability to have or keep an erection

For children

More common

Constipation

feeling of warmth

nausea

redness of the face, neck, arms and occasionally, upper chest

stomach pain

vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Lupron Depot-Ped (leuprolide)

thumbs-up

Pros

Works well to prevent precocious puberty (early puberty)

Well-tolerated with few side effects

Injections are only needed once every month, every 3 months, or every 6 months.

thumbs-down

Cons

Only available as an injection

Might cause mood or emotional changes the first few weeks

Requires close follow-up with routine blood draws and labs

pharmacist-tips

Pharmacist tips for Lupron Depot-Ped (leuprolide)

pharmacist

  • Lupron Depot-Ped (leuprolide) is given in a healthcare provider's office for girls under 8 years or boys under 9 years to help prevent them from starting puberty too early.

    • During the first 2 to 4 weeks of treatment, Lupron Depot-Ped (leuprolide) can cause your child's hormone levels to go up, resulting in more signs of puberty at first. These signs include vaginal bleeding. Call your child's healthcare provider if these symptoms continue beyond the second month of treatment.

      • Sudden mood changes, such as crying, irritability, impatience, anger, and aggression, have been observed in children taking Lupron Depot-Ped (leuprolide).

        • After injection, some pain and irritation is expected, but if more serious symptoms occur, call your healthcare provider.

          • It's important to have your child visit their healthcare provider regularly for blood tests to have the most success.

            faqs

            Frequently asked questions about Lupron Depot-Ped (leuprolide)

            What is precocious puberty?
            Precocious puberty is when children have signs of sexual development (e.g., breast enlargement, penile enlargement, vaginal bleeding, pubic hair) younger than normally seen. Children with early sexual development younger than the age of eight (girls) or nine (boys) years should be seen by their healthcare provider.
            Does Lupron Depot-Ped (leuprolide) cause pain?
            In clinical trials, one of the most common side effects reported was pain at the site where the medication was injected.
            Does Lupron Depot-Ped (leuprolide) cause mental health problems?
            Some people taking Lupron Depot-Ped (leuprolide) might experience more crying, anger, irritability, or restlessness (impatience). If your child has a history of emotional or mental health problems, let his or her healthcare provider know before starting this medication.
            Where is Lupron Depot-Ped (leuprolide) injected?
            Lupron Depot-Ped (leuprolide) can be injected into the shoulder muscle, thigh muscle, or the buttock muscle. Fensolvi (the other version of this medication) is injected underneath the skin instead (usually under skin in the stomach or buttocks).
            Should I store my medication in the fridge?
            No, Lupron Depot-Ped (leuprolide) should be stored at room temperature, which is about 77ºF.
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            What are the risks and warnings for Lupron Depot-Ped (leuprolide)?

            Lupron Depot-Ped (leuprolide) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            Initial worsening of symptoms

            Lupron Depot-Ped (leuprolide) is an artificial (man-made) hormone similar to one your body makes, called gonadotropin-releasing hormone (GnRH). Similar to other GnRH medications, Lupron Depot-Ped (leuprolide) can cause worsening of puberty symptoms, such as vaginal bleeding, when first started. These symptoms should go away within the first 4 weeks of therapy.

            risk-warning

            Emotional or mental health changes

            People taking medications similar to GnRH, like Lupron Depot-Ped (leuprolide), may have trouble controlling their emotions. Symptoms of emotional changes include crying, irritability, impatience, anger, and aggression. As a parent, watch your child for changes in behavior or emotions.

            risk-warning

            Convulsions (seizures)

            • Risk factors: History of seizures | History of stroke | People taking certain mental health medications, including SSRIs or bupropion (Wellbutrin)

              People taking medications similar to GnRH, like Lupron Depot-Ped (leuprolide), may experience convulsions or seizures. This is more likely to happen if your child has had seizures or strokes in the past or if they take certain mental health medications, such as selective serotonin reuptake inhibitors (SSRIs, like sertraline (Zoloft)) or bupropion (Wellbutrin). If you notice your child is experiencing tight muscles, uncontrollable movements, or painful cramping, call their healthcare provider right away.

              dosage

              Lupron Depot-Ped (leuprolide) dosage forms

              Typical dosing for Lupron Depot-Ped (leuprolide)

              Lupron Depot-Ped (leuprolide) must be given by your child's healthcare provider. The dose is based on your child's body weight. Your child's healthcare provider will follow up every 1 to 2 months to make sure the medication is working.

              Lupron Depot-Ped (leuprolide) is injected into the thigh, shoulder, or buttock muscle. The medication can either be injected once every month or once every 3 months.

              There is another brand name of this medication called Fensolvi, which is injected under the skin in the stomach or buttock area once every 6 months.

              interactions

              Interactions between Lupron Depot-Ped (leuprolide) and other drugs

              Lupron Depot-Ped (leuprolide) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Lupron Depot-Ped (leuprolide). Please note that only the generic name of each medication is listed below.

              Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

              Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

              alternatives

              What are alternatives to Lupron Depot-Ped (leuprolide)?

              There are a number of medications that your doctor can prescribe in place of Lupron Depot-Ped (leuprolide). Compare a few possible alternatives below.
              Lupron Depot-Ped (leuprolide)
              Used for:

              • Precocious puberty (puberty that starts at an early age)

              View Prices
              Supprelin LA (histrelin)
              Used for:

              • Precocious puberty (puberty that starts at an early age)

              View Prices
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              Lupron Depot-Ped (leuprolide) images

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