Lupron Depot Injection
Leuprolide acetate is used to treat advanced prostate cancer. This medication is either injected under the skin or into your muscle. The brand name formulations of leuprolide acetate must be given by a healthcare provider.
What is Leuprolide acetate?
What is Leuprolide acetate used for?
Advanced prostate cancer
How Leuprolide acetate works
Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist, which is a synthetic (lab-made) hormone similar to the GnRH your body naturally makes. Over time, it lowers testosterone levels, which helps slow down the growth of the prostate gland and cancer cells.
Drug Facts
What are the side effects of Leuprolide acetate?
Common Side Effects
- Hot flashes or sweats
- Injection site reaction (e.g., burning, stinging)
- Pain (e.g., general, muscle, bone, joint)
- Tiredness
- Swelling
- Breathing problems
- Digestive system problems
- Urinary problems
- Shrinking of testicles
- High blood pressure
Other Side Effects
- Headache
- Weakness
- Dizziness
- Trouble sleeping
- Waking up at night to urinate
- Lowered sex drive
- Difficulty getting or keeping an erection
- Upper respiratory tract infection (e.g., common cold)
Serious Side Effects
- Heart problems: racing heart, fluttering in your chest, abnormal heartbeats, heart attack, stroke
- Convulsions (seizures): tight muscles, uncontrollable movements, painful cramping
Source:Â DailyMed
The following side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
For adults
Less common
Fast or irregular heartbeat
For males only (adults)
More common
Arm, back, or jaw pain
bloody or cloudy urine
blurred vision
chest pain or discomfort
difficult, burning, or painful urination
difficulty with moving
dizziness
frequent urge to urinate
headache
increased urge to urinate during the night
muscle pain or stiffness
nervousness
pain in the joints
pale skin
pounding in the ears
slow or fast heartbeat
sweating
unusual bleeding or bruising
unusual tiredness or weakness
waking to urinate at night
Rare
Pain in the groin or legs (especially in the calves)
Incidence not known
Altered mental status
cold, clammy, pale skin
confusion
double vision
irregular heartbeat
visual changes
vomiting
For females only (adults)
For children
More common
Body aches or pain
chills
cough producing mucus
difficulty in breathing
ear congestion
headache
loss of voice
muscle aches
noisy breathing
pain or redness at the injection site
runny or stuffy nose
tightness in the chest
unusual tiredness or weakness
Less common
Irritability
mood or mental changes
Rare
Burning, itching, or swelling at the injection site
Incidence not known
Seizures
For females only (children)—expected in first few weeks
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For adults
More common
Sudden sweating and feeling of warmth (hot flashes)
For females only (adults)
For males only (adults)
More common
Back pain
chills
general feeling of discomfort or illness
loss of appetite
pain or discomfort at the injection site
redness of the face, neck, arms, and occasionally, upper chest
shivering
unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
Less common
Decreased size of the testicles
inability to have or keep an erection
For children
More common
feeling of warmth
redness of the face, neck, arms and occasionally, upper chest
stomach pain
vomiting
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Pros and cons of Leuprolide acetate
Pros
Works well to lower testosterone levels
Lowers testosterone levels in about a month
Can choose how often you get your injections, depending on the formulation, brand name, and dose: every month, every 3 months, every 4 months, or every 6 months
Cons
Not a cure for prostate cancer; only helps slow cancer growth
Requires close follow up with regular blood draws and labs
Only available as an injection
No lower-cost generic available and must be given by a provider
Pharmacist tips for Leuprolide acetate
Leuprolide acetate raises your testosterone levels in the first few weeks before they go down. This can cause a flare-up in your prostate cancer symptoms, such as bone pain, bladder pain, blood in your urine, trouble urinating, or weakness. Let your provider know if these symptoms don't go away after a month.
Your healthcare provider will check your labs regularly to make sure leuprolide acetate is working.
Leuprolide acetate can sometimes make it difficult for you to get or maintain an erection. This is a normal side effect. The medication lowers your testosterone levels, which can affect your ability to have an erection. Ask your provider if you have any concerns if you experience this problem.
It's possible for leuprolide acetate to affect the ability in males to have children. Discuss this possibility with your healthcare provider before starting leuprolide acetate.
Frequently asked questions about Leuprolide acetate
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What are the risks and warnings for Leuprolide acetate?
Leuprolide acetate can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Initial worsening of symptoms
Leuprolide acetate is a lab-made medication that works similarly to the gonadotropin-releasing hormone (GnRH) your body naturally makes. Similar to other GnRH medications, leuprolide acetate temporarily causes your testosterone levels to go up when you first start treatment. This can make your prostate cancer symptoms worse, usually during the first few weeks of starting the medication. Your testosterone levels should drop and your symptoms should get better after those first few weeks. Let your provider know if you experience any bone pain, bladder pain, or blood in your urine that doesn't go away in about a month.
Higher blood sugar levels and risk of diabetes
Males using leuprolide acetate have reported a rise in their blood sugars. This puts them at greater risk of developing new or worsening diabetes. Your healthcare provider will regularly check your labs to make sure your blood sugar levels and other blood-sugar related lab values are normal.
Heart problems
Risk factors: History of heart rhythm problems or heart failure | Electrolyte imbalances | Taking certain heart rhythm medications, mental health medications, or antibiotics
Although the risk is low, males who use leuprolide acetate might be at risk of having heart problems. These problems can include heart attack, stroke, or sudden cardiac (heart-related) death. Before starting the medication, your provider will check for your risk for heart problems. Get emergency help right away if you experience chest or arm pain, shortness of breath, a cold sweat, weakness on one side of the body, drooping face, bad headache, or trouble walking or speaking. These can be signs of a heart attack or stroke.
Medications similar to leuprolide acetate can also cause irregular heart rhythms. Before starting treatment, let your provider know if you have any conditions causing irregular heart rhythms, heart failure, or electrolyte problems. Your provider will discuss with you about the risks and benefits of taking leuprolide acetate with your condition.
Convulsions (seizures)
Risk factors: History of seizures | History of stroke | Taking certain medications including SSRIs or bupropion (Wellbutrin)
Some people using leuprolide acetate have experienced convulsions or seizures. This is more likely to happen if you've had seizures or strokes in the past or if you take certain mental health medications, such as selective serotonin reuptake inhibitors (SSRIs, like sertraline (Zoloft)) or bupropion (Wellbutrin). If you or a loved one notices that you have signs of a seizure like tight muscles, uncontrollable movements, or painful cramping, call your healthcare provider right away.
Possible spinal cord and urinary tract problems
Risk factors: History of spine problems | History of urinary tract problems
There have been a few cases of spinal cord compression, or pressure on the spinal cord, in people taking leuprolide acetate. This can possibly lead to paralysis (not being able to move). Also, some people have gotten a blockage in their urinary tract during treatment. This can lead to kidney damage or urinary problems. These problems might happen during the first few weeks of treatment. Talk to your healthcare provider about your medical history or your concerns about the medication before starting leuprolide acetate.
Leuprolide acetate dosage forms
Typical dosing for Leuprolide acetate
Lupron Depot: The typical dosing range is 7.5 mg to 45 mg injected into your muscle by a healthcare provider. Depending on the dose, the medication is injected every month, every 3 months, every 4 months, or every 6 months. It's either injected in your shoulder, buttock, or outer thigh muscle.
Eligard: The typical dosing range is 7.5 mg to 45 mg injected under the skin by a healthcare provider. Depending on the dose, the medication is injected every month, every 3 months, every 4 months, or every 6 months. It's usually injected under the skin in your stomach or upper buttock area.
Camcevi: The typical dose is 42 mg injected under the skin every 6 months by a healthcare provider. It's injected under the skin in your stomach.
Interactions between Leuprolide acetate and other drugs
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Bepridil
- Cisapride
- Dronedarone
- Mesoridazine
- Pimozide
- Piperaquine
- Saquinavir
- Sparfloxacin
- Terfenadine
- Thioridazine
- Ziprasidone
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Amiodarone
- Amisulpride
- Aripiprazole Lauroxil
- Buprenorphine
- Buserelin
- Ceritinib
- Citalopram
- Clofazimine
- Degarelix
- Deslorelin
- Deutetrabenazine
- Donepezil
- Encorafenib
- Entrectinib
- Formoterol
- Fostemsavir
- Glasdegib
- Gonadorelin
- Goserelin
- Histrelin
- Hydroxychloroquine
- Hydroxyzine
- Inotuzumab Ozogamicin
- Ivosidenib
- Lefamulin
- Lenvatinib
- Lofexidine
- Macimorelin
- Methotrimeprazine
- Mirtazapine
- Moricizine
- Nafarelin
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Ozanimod
- Papaverine
- Pimavanserin
- Pitolisant
- Ponesimod
- Ribociclib
- Selpercatinib
- Sertraline
- Siponimod
- Sotalol
- Sulpiride
- Sunitinib
- Triclabendazole
- Triptorelin
- Vemurafenib
- Voclosporin
- Zotepine
- Zuclopenthixol
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