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Sirturo

Sirturo Side Effects

Aileen Chu, PharmD, BCPSCydnee Ng, PharmD
Reviewed by Aileen Chu, PharmD, BCPS, Cydnee Ng, PharmD
Last reviewed on September 9, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea (38%)
  • Joint pain (33%)
  • Headache (28%)
  • Coughing up blood (18%)
  • Chest pain (11%)
  • Low appetite (9%)
  • Higher liver enzyme levels (9%)
  • Rash (8%)

Note: Side effects were reported in adults taking [[EDITOR|DRUG_DISPLAY_NAME]] with other TB medications. Side effects might differ in children.

Sirturo serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Heart rhythm problems: palpitations, chest pain, dizziness, lightheadedness, shortness of breath, fainting
  • Liver problems: tiredness, loss of appetite, nausea, liver feeling tender, dark urine, yellowing of the skin or whites of the eyes

Source: DailyMed

The following Sirturo side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Chest pain

coughing or spitting up blood

dark-colored urine

decreased appetite

fever

general feeling of tiredness or weakness

headache

itching or skin rash

light-colored stools

loss of appetite

nausea and vomiting

stomach pain or tenderness

swelling of the feet or lower legs

unusual tiredness or weakness

yellow eyes or skin

Incidence not known

Dizziness or fainting

fast or irregular heartbeat

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Difficulty with moving

muscle pain or stiffness

pain in the joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Aileen Chu, PharmD, has over 8 years of experience working as a clinical pharmacist in the emergency department. Chu is also a pharmacotherapeutics instructor at Point Loma Nazarene University.
Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.

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