Rykindo (risperidone) is a long-acting injectable antipsychotic that's used to treat schizophrenia and bipolar 1 disorder. Your healthcare provider will inject this medication into the buttock muscle every 2 weeks. The most common side effects you might experience from Rykindo (risperidone) include movement problems, weight gain, and drowsiness.
Schizophrenia in adults
Rykindo (risperidone) is an atypical antipsychotic. It's not completely known how Rykindo (risperidone) works, but it's thought to work by balancing out the levels of chemicals (dopamine and serotonin) in your brain to help control your thoughts, mood, and behaviors.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Good option for people who don't want to take a daily pill
Given every 2 weeks
Hasn't been studied in children
Need to go to provider's office or clinic to receive injection
Make sure to mark your Rykindo (risperidone) appointments in your calendar so you don't miss any of your doses.
Rykindo (risperidone) interacts with a lot of commonly-used medications, such as certain selective serotonin reuptake inhibitor (SSRIs) and blood pressure medications. Let your provider know about all the medications you're taking before starting Rykindo (risperidone). Don't start any new medications without talking to your provider or pharmacist first.
Avoid alcohol while taking Rykindo (risperidone) because it can worsen side effects (e.g., drowsiness, dizziness) and the symptoms of schizophrenia and bipolar disorder.
Rykindo (risperidone) can make you sleepy and dizzy. Don't drive or do anything requiring concentration until you know how this medication affects you.
Rykindo (risperidone) can raise your blood sugar levels. If you have diabetes, ask your provider if you need to check your blood sugar more often while taking Rykindo (risperidone).
Rykindo (risperidone) can raise cholesterol (fat) levels in your blood and can cause weight gain. It's important that you eat a healthy and balanced diet low in fat and sugar and maintain a regular exercise routine while taking Rykindo (risperidone).
Rykindo (risperidone) can cause a drop in blood pressure when moving positions, such as from sitting to standing. This is more common when starting treatment and when your dose changes. Make sure to get up slowly and try to hold onto something for stability. If you end up falling or hitting your head, get medical help right away.
Although rare, Rykindo (risperidone) can cause difficulty swallowing, which can raise the risk for choking. Make sure to take small bites of food and eat slowly to lower your risk for choking.
Rykindo (risperidone) can make it harder for your body to cool down if your body temperature gets too high. This makes it more likely for you to become dehydrated and your body to overheat. Let your healthcare provider know if you feel very hot or thirsty, notice a change in the amount of sweat or urine you make, or if you notice very dark-colored urine.
Rykindo (risperidone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Older adults with dementia-related psychosis
People over the age of 65 who also have dementia sometimes have some of the symptoms of schizophrenia, like hallucinations and delusions. This is called dementia-related psychosis, and it should not be treated with Rykindo (risperidone). If Rykindo (risperidone) is used for dementia-related psychosis, it can cause death. In clinical studies, the cause of death is often linked to stroke or other blood vessel problems. Let your provider know if you or your loved one has dementia before starting Rykindo (risperidone).
Taking antipsychotic medications like Rykindo (risperidone) can cause a rare, but life-threatening condition called neuroleptic malignant syndrome. Symptoms include fever, sweating, stiff muscles, confusion, being unaware of your surroundings, and fast or irregular heartbeat. If you experience any of these symptoms while taking Rykindo (risperidone), get medical attention as soon as possible. You provider will likely have you stop taking Rykindo (risperidone) and switch you to something else.
Risk factors: Older adults | Female and 65 years or older | Higher than recommended doses of Rykindo (risperidone) | Taking Rykindo (risperidone) for a long time
Rykindo (risperidone) can cause uncontrolled and possibly permanent muscle movements in the tongue, face, mouth, lips, neck, hands, arms, legs, and feet (tardive dyskinesia). To lower your risk of tardive dyskinesia, your provider will have you take the lowest dose possible for the shortest period of time for your symptoms. Stop taking Rykindo (risperidone) and talk to your provider right away if you notice any unusual movements you can't control.
Risk factors: Diabetes | High cholesterol | Identified as obese
Rykindo (risperidone) can raise your blood sugar and cholesterol levels as well as raise your appetite, all of which can lead to weight gain. Your provider will likely order blood tests regularly throughout treatment with Rykindo (risperidone) to make sure your blood sugar and cholesterol aren't too high. Make sure to have a healthy and balanced diet low in fat and sugar and maintain a regular exercise routine while receiving Rykindo (risperidone).
Rykindo (risperidone) can raise the level of prolactin hormones in your body. High prolactin levels can lead to symptoms such as milky substances being released from the nipple, enlarged breasts, and absent or irregular menstrual periods. Talk to your healthcare provider if you experience or have any concerns about these symptoms.
Risk factors: Low blood pressure | Taking medications that lower blood pressure | History of medical conditions that can lower blood pressure | High Rykindo (risperidone) doses | Liver or kidney problems | 65 years or older
Rykindo (risperidone) can make you tired, lower your blood pressure, or cause you to lose your balance, which can lead to falls. When standing from a sitting or lying position, make sure to get up slowly and hold onto something. If you experience a fall while taking Rykindo (risperidone), contact your provider.
Risk factors: Poor immune system
Though rare, Rykindo (risperidone) can lower your white blood cell counts (WBCs) and put you at risk for developing infections. You might need to get blood tests done regularly during the first few months of taking Rykindo (risperidone) so your provider can make sure your WBCs are in a safe range. If your WBC count drops too low, you'll likely need to stop taking Rykindo (risperidone). If you develop any signs of infection, such as fever, tiredness, chills, cough, or trouble breathing, and they don't go away, contact your provider right away.
Risk factors: Taking high doses of Rykindo (risperidone) | Age 65 years or older | Drinking alcohol | Taking other medications that can cause sleepiness
Rykindo (risperidone) can cause extreme sleepiness and lower your ability to think, react, and focus. Your risk is higher if you're also taking other medications that can cause drowsiness, such as benzodiazepines, anxiety medications, muscle relaxants, and sleep medications. Make sure you know how this medication affects you before driving a car or doing activities that require your concentration. Talk to your healthcare provider right away if you feel too sleepy from Rykindo (risperidone).
Risk factors: History of seizures | Health conditions that make it easier to get seizures
Rykindo (risperidone) can potentially cause seizures. Before starting this medication, let your provider know if you have a history of seizures or have a medical condition that puts you at risk for getting seizures.
Although rare, Rykindo (risperidone) can cause prolonged and painful erections, which sometimes requires surgery to treat. If you develop a prolonged erection that lasts longer than 4 hours, get medical attention right away.
The typical dose is 25 mg injected into the buttock muscle every 2 weeks. The maximum dose is 50 mg every 2 weeks.
Your dose might differ if you're taking a medication that interacts with Rykindo (risperidone), or if you have kidney or liver problems.
Allergy to risperidone or paliperidone (Invega)
Schizophrenia in adults
Bipolar 1 disorder in adults
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National Institute of Mental Health. (2023). Schizophrenia.
Shandong Luye Pharmaceutical Co., Ltd. (2023). Rykindo extended-release microspheres- risperidone kit [package insert]. DailyMed.
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