Rykindo
Rykindo (risperidone) is a long-acting injectable antipsychotic that's used to treat schizophrenia and bipolar 1 disorder. Your healthcare provider will inject this medication into the buttock muscle every 2 weeks. The most common side effects you might experience from Rykindo (risperidone) include movement problems, weight gain, and drowsiness.
What is Rykindo (risperidone)?
What is Rykindo (risperidone) used for?
- Schizophrenia in adults
- Bipolar 1 disorder
How Rykindo (risperidone) works
Rykindo (risperidone) is an atypical antipsychotic. It's not completely known how Rykindo (risperidone) works, but it's thought to work by balancing out the levels of chemicals (dopamine and serotonin) in your brain to help control your thoughts, mood, and behaviors.
Drug facts
Side effects of Rykindo (risperidone)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Headache (15-21%)
- Muscle stiffness, rigid movements (8-15%)
- Dizziness (7-11%)
- Restlessness (4-11%)
- Tiredness (3-9%)
- Constipation (5-7%)
- Dry mouth (7%)
- Indigestion (6%)
- Sleepiness (5-6%)
- Weight gain (4-5%)
Less Common Side Effects
- Weight loss
- Blurry vision
- Nausea
- Drooling
- Swelling in arms/legs
- Fever
- Shakiness
- Feeling faint
- Cough
Please note: Side effects listed here were reported by people using another long-acting risperidone muscle injection for schizophrenia in clinical studies.
Rykindo (risperidone) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Neuroleptic malignant syndrome: fever, sweating, stiff muscles, confusion, not aware of your surroundings, fast or irregular heartbeat
- Dangerously high blood sugar: frequently thirsty, needing to urinate often, tiredness, nausea, vomiting, difficulty breathing, having fruity breath, having dry mouth
- Serious infections: fever, headache, chills, body aches, cough, weakness
- Seizures
- Difficulty swallowing
The following Rykindo (risperidone) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
- High fever, stiff muscles, increased sweating, fast or irregular heartbeat, and confusion, which may be signs of neuroleptic malignant syndrome
- High prolactin level—unexpected breast tissue growth, discharge from the nipple, change in sex drive or performance, irregular menstrual cycle
- Infection—fever, chills, cough, or sore throat
- Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
- Pain or trouble swallowing
- Prolonged or painful erection
- Seizures
- Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
- Uncontrolled and repetitive body movements, muscle stiffness or spasms, tremors or shaking, loss of balance or coordination, restlessness, shuffling walk, which may be signs of extrapyramidal symptoms (EPS)
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
- Constipation
- Drowsiness
- Muscle pain or cramps
- Weight gain
Pros and cons of Rykindo (risperidone)
Pros
- Good option for people who don't want to take a daily pill
- Given every 2 weeks
Cons
- Hasn't been studied in children
- Need to go to provider's office or clinic to receive injection
Pharmacist tips for Rykindo (risperidone)
- Make sure to mark your Rykindo (risperidone) appointments in your calendar so you don't miss any of your doses.
- Rykindo (risperidone) interacts with a lot of commonly-used medications, such as certain selective serotonin reuptake inhibitor (SSRIs) and blood pressure medications. Let your provider know about all the medications you're taking before starting Rykindo (risperidone). Don't start any new medications without talking to your provider or pharmacist first.
- Avoid alcohol while taking Rykindo (risperidone) because it can worsen side effects (e.g., drowsiness, dizziness) and the symptoms of schizophrenia and bipolar disorder.
- Rykindo (risperidone) can make you sleepy and dizzy. Don't drive or do anything requiring concentration until you know how this medication affects you.
- Rykindo (risperidone) can raise your blood sugar levels. If you have diabetes, ask your provider if you need to check your blood sugar more often while taking Rykindo (risperidone).
- Rykindo (risperidone) can raise cholesterol (fat) levels in your blood and can cause weight gain. It's important that you eat a healthy and balanced diet low in fat and sugar and maintain a regular exercise routine while taking Rykindo (risperidone).
- Rykindo (risperidone) can cause a drop in blood pressure when moving positions, such as from sitting to standing. This is more common when starting treatment and when your dose changes. Make sure to get up slowly and try to hold onto something for stability. If you end up falling or hitting your head, get medical help right away.
- Although rare, Rykindo (risperidone) can cause difficulty swallowing, which can raise the risk for choking. Make sure to take small bites of food and eat slowly to lower your risk for choking.
- Rykindo (risperidone) can make it harder for your body to cool down if your body temperature gets too high. This makes it more likely for you to become dehydrated and your body to overheat. Let your healthcare provider know if you feel very hot or thirsty, notice a change in the amount of sweat or urine you make, or if you notice very dark-colored urine.
Common questions about Rykindo (risperidone)
Rykindo, Risperdal Consta, and Uzedy are long-acting risperidone injections for adults. All three medications are given by a healthcare provider. Before you start any of them, your provider will have you take oral risperidone (Risperdal) first to see if the medication works well for you and whether you have any serious side effects. Once your provider thinks that a long-acting risperidone injection is appropriate for you, they'll discuss with you possible options based on your medical condition, personal preference, and insurance coverage. For example, all three medications are FDA-approved for schizophrenia, but only Risperdal Consta and Rykindo are approved for bipolar disorder. Uzedy is injected under the skin every 1 to 2 months, whereas Risperdal Consta and Rykindo are injected into the muscle every 2 weeks. Ask your provider if you've more questions about the differences between the long-acting injections.
Yes, your provider will ask you to take risperidone (Risperdal) first before deciding whether you can switch over to Rykindo (risperidone). This is because taking oral risperidone (Risperdal) first will help you and your provider understand how well this medication works for you and whether you might experience any serious side effects. If the oral tablets work well, then your provider will likely consider Rykindo (risperidone) as a long-acting option for you. To properly switch, you'll need to receive Rykindo (risperidone) and take oral risperidone (Risperdal) for 7 days.
It can, but it's also possible for it to cause weight loss too. In studies looking at the side effects of a long-acting risperidone injection like Rykindo (risperidone), 4-5% of people gained weight while 1-4% of people lost weight, depending on the dose. To lower your risk for weight gain while taking Rykindo (risperidone), make sure to have a healthy diet and regular exercise routine. Contact your provider if you're uncomfortable with how much weight you've gained or lost while on Rykindo (risperidone). They might give you medications to treat the weight gain or switch you to a different medication.
Yes, Rykindo (risperidone) can cause sleepiness and tiredness as side effects. However, some people also experience other sleep problems while taking Rykindo (risperidone), including trouble falling asleep or vivid dreams. When you first start Rykindo (risperidone), pay attention to how this medication is affecting your sleep. If it's making you too sleepy or interrupting your sleep, contact your provider. They can try to ease this side effect by making changes to your dose or the timing of when you take this medication.
No, Rykindo (risperidone) can only be given by a healthcare provider. You'll receive Rykindo (risperidone) at your provider's office or clinic. During your appointment to receive your Rykindo (risperidone) dose, your provider will likely ask you questions to see how well the medication is working for you and if you're having side effects.
No, Rykindo (risperidone) isn't a controlled substance because it doesn't have a risk of addiction, misuse, or dependence.
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Risks and warnings for Rykindo (risperidone)
Rykindo (risperidone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Higher risk of death in older adults with dementia-related psychosis
- Risk factors: Older adults with dementia-related psychosis
People over the age of 65 who also have dementia sometimes have some of the symptoms of schizophrenia, like hallucinations and delusions. This is called dementia-related psychosis, and it should not be treated with Rykindo (risperidone). If Rykindo (risperidone) is used for dementia-related psychosis, it can cause death. In clinical studies, the cause of death is often linked to stroke or other blood vessel problems. Let your provider know if you or your loved one has dementia before starting Rykindo (risperidone).
Neuroleptic malignant syndrome
Taking antipsychotic medications like Rykindo (risperidone) can cause a rare, but life-threatening condition called neuroleptic malignant syndrome. Symptoms include fever, sweating, stiff muscles, confusion, being unaware of your surroundings, and fast or irregular heartbeat. If you experience any of these symptoms while taking Rykindo (risperidone), get medical attention as soon as possible. You provider will likely have you stop taking Rykindo (risperidone) and switch you to something else.
Difficulty controlling muscle movements (tardive dyskinesia)
- Risk factors: Older adults | Female and 65 years or older | Higher than recommended doses of Rykindo (risperidone) | Taking Rykindo (risperidone) for a long time
Rykindo (risperidone) can cause uncontrolled and possibly permanent muscle movements in the tongue, face, mouth, lips, neck, hands, arms, legs, and feet (tardive dyskinesia). To lower your risk of tardive dyskinesia, your provider will have you take the lowest dose possible for the shortest period of time for your symptoms. Stop taking Rykindo (risperidone) and talk to your provider right away if you notice any unusual movements you can't control.
Weight gain, higher blood sugar, and higher cholesterol levels
- Risk factors: Diabetes | High cholesterol | Identified as obese
Rykindo (risperidone) can raise your blood sugar and cholesterol levels as well as raise your appetite, all of which can lead to weight gain. Your provider will likely order blood tests regularly throughout treatment with Rykindo (risperidone) to make sure your blood sugar and cholesterol aren't too high. Make sure to have a healthy and balanced diet low in fat and sugar and maintain a regular exercise routine while receiving Rykindo (risperidone).
High prolactin levels
Rykindo (risperidone) can raise the level of prolactin hormones in your body. High prolactin levels can lead to symptoms such as milky substances being released from the nipple, enlarged breasts, and absent or irregular menstrual periods. Talk to your healthcare provider if you experience or have any concerns about these symptoms.
Changes in blood pressure and higher risk of falls
- Risk factors: Low blood pressure | Taking medications that lower blood pressure | History of medical conditions that can lower blood pressure | High Rykindo (risperidone) doses | Liver or kidney problems | 65 years or older
Rykindo (risperidone) can make you tired, lower your blood pressure, or cause you to lose your balance, which can lead to falls. When standing from a sitting or lying position, make sure to get up slowly and hold onto something. If you experience a fall while taking Rykindo (risperidone), contact your provider.
Risk of infection (from low white blood cell count)
- Risk factors: Poor immune system
Though rare, Rykindo (risperidone) can lower your white blood cell counts (WBCs) and put you at risk for developing infections. You might need to get blood tests done regularly during the first few months of taking Rykindo (risperidone) so your provider can make sure your WBCs are in a safe range. If your WBC count drops too low, you'll likely need to stop taking Rykindo (risperidone). If you develop any signs of infection, such as fever, tiredness, chills, cough, or trouble breathing, and they don't go away, contact your provider right away.
Difficulty concentrating and extreme sleepiness
- Risk factors: Taking high doses of Rykindo (risperidone) | Age 65 years or older | Drinking alcohol | Taking other medications that can cause sleepiness
Rykindo (risperidone) can cause extreme sleepiness and lower your ability to think, react, and focus. Your risk is higher if you're also taking other medications that can cause drowsiness, such as benzodiazepines, anxiety medications, muscle relaxants, and sleep medications. Make sure you know how this medication affects you before driving a car or doing activities that require your concentration. Talk to your healthcare provider right away if you feel too sleepy from Rykindo (risperidone).
Seizures
- Risk factors: History of seizures | Health conditions that make it easier to get seizures
Rykindo (risperidone) can potentially cause seizures. Before starting this medication, let your provider know if you have a history of seizures or have a medical condition that puts you at risk for getting seizures.
Prolonged and painful erection
Although rare, Rykindo (risperidone) can cause prolonged and painful erections, which sometimes requires surgery to treat. If you develop a prolonged erection that lasts longer than 4 hours, get medical attention right away.
Rykindo (risperidone) dosage
Typical dosage for Rykindo (risperidone)
The typical dose is 25 mg injected into the buttock muscle every 2 weeks. The maximum dose is 50 mg every 2 weeks.
Your dose might differ if you're taking a medication that interacts with Rykindo (risperidone), or if you have kidney or liver problems.
Rykindo (risperidone) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Rykindo (risperidone) will not be safe for you to take.
- Allergy to risperidone or paliperidone (Invega)
