The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Weakness, tingling, or numbness of hands and feet (81%)
- Acne (39%)
- Low red blood cell count (anemia; 37%)
- Nausea (37%)
- Vomiting (34%)
- Muscle, joint, or back pain (29%)
- Headache (28%)
- Higher liver enzymes (28%)
- Heartburn (24%)
- Low appetite (22%)
- Rash (21%)
- Itchiness (20%)
- Stomach pain (19%)
- Sharp chest pain (19%)
- Respiratory tract infection (e.g., bronchitis, pneumonia; 15%)
- Coughing up blood (13%)
- Cough (12%)
- Vision problems (12%)
*Side effects seen in combination with Sirturo (bedaquiline) and linezolid (Zyvox)
Less Common Side Effects
- Low blood sugar
- Abnormal weight loss
- Diarrhea
- Constipation
- Dry skin
- Trouble sleeping
Pretomanid serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Liver damage: dark urine, right-side stomach pain, yellowing of the eyes or skin, tiredness, loss of appetite, nausea, vomiting
- Bleeding or bruising that doesn't stop or go away
- Low white blood cell count: repeated fevers or infections
- Abnormal heart rhythm: abnormally fast heart rate, fainting
Source: DailyMed
The following Pretomanid side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Cough
- Headache
- Nausea
- Stomach pain
- Upset stomach
- Vomiting
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